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12/14/2017 1:22:49 AM | Browse: 496 | Download: 778
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Received |
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2017-09-01 00:14 |
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Peer-Review Started |
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2017-09-03 07:49 |
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To Make the First Decision |
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2017-09-20 00:06 |
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Return for Revision |
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2017-09-21 08:42 |
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Revised |
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2017-10-01 02:40 |
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Second Decision |
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2017-11-01 07:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-11-01 21:09 |
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Articles in Press |
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2017-11-01 21:09 |
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Publication Fee Transferred |
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2017-11-06 07:21 |
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Edit the Manuscript by Language Editor |
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2017-11-14 13:13 |
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Typeset the Manuscript |
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2017-11-26 09:44 |
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Publish the Manuscript Online |
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2017-12-04 08:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Wei Li, Chong Zhang, Qiu-Ju Sheng, Han Bai, Yang Ding and Xiao-Guang Dou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Liaoning Provincial Science and Technology Key Project for Translational Medicine |
2014225020 |
| Outstanding Scientific Fund of Shengjing Hospital |
201102 |
| Liaoning Provincial Science and Technology Key Project for Translational Medicine |
2016509 |
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| Corresponding Author |
Xiao-Guang Dou, PhD, Chief Doctor, Department of Infectious Diseases, Shengjing Hospital of China Medical University, Huaxiang Street, Shenyang 110022, Liaoning Province, China. douxg@sj-hospital.org |
| Key Words |
Acute hepatic failure; Mesenchymal stem cells; Macrophages; Polarization; Inflammation |
| Core Tip |
M1 or M2 polarization governs the therapeutic effect of acute hepatic failure (AHF). Mesenchymal stem cells (MSCs) were transfused into rats with AHF induced by galactosamine. It was found that MSCs alleviated the survival rate and biochemical indicators by promoting hepatocyte regeneration. Immunohistochemistry, flow cytometry, and RT-PCR showed that M2 polarization contributes to the rescue of AHF by MSCs in the survival group after MSC transplantation. In addition, in the death group after MSC transplantation, the number of M1 macrophages increased significantly. Our findings suggest that M2 polarization contributes to the rescue of AHF by MSCs, which result in altered levels of anti-inflammatory and pro-inflammatory factors. |
| Publish Date |
2017-12-04 08:09 |
| Citation |
Li YW, Zhang C, Sheng QJ, Bai H, Ding Y, Dou XG. Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages. World J Gastroenterol 2017; 23(45): 7978-7988 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i45/7978.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i45.7978 |
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