Publication Name	World Journal of Transplantation
Manuscript ID	39055
Country	Netherlands

Received	2018-04-24 07:57
Peer-Review Started	2018-04-24 17:24
To Make the First Decision	2018-06-08 03:05
Return for Revision	2018-06-08 07:34
Revised	2018-06-14 15:55
Second Decision	2018-06-26 12:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-27 23:46
Articles in Press	2018-06-27 23:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-06 04:09
Publish the Manuscript Online	2018-09-07 06:15

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Basic Study
Article Title	Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid
Manuscript Source	Invited Manuscript
All Author List	Petra E de Ruiter, Yashna Gadjradj, Robert de Knegt, Herold J Metselaar, Jan NM IJzermans and Luc JW van der Laan
Funding Agency and Grant Number
Corresponding Author	Luc JW van der Laan, MSc, PhD, Associate Professor, Laboratory of Experimental Transplantation and Intestinal Surgery, Department of Surgery, Erasmus MC-University Medical Center, Room Na1006, Wytemaweg 80, Rotterdam CN 3015, Netherlands. l.vanderlaan@erasmusmc.nl
Key Words	Immunosuppressant; Hepatitis C; Daclatasvir; Asunaprevir; Liver; Transplantation
Core Tip	Since 2013, several new generation direct acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV), including daclatasvir (DCV) and asunaprevir (ASV). Although a few reports investigated the effectivity of DAAs after liver transplantation, the effects of specific immunosuppressants on the antiviral efficacy remain largely unknown. We investigated the effect of the immunosuppressants on the antiviral action of DCV and ASV in two in vitro models for HCV. We observed that none of the immunosuppressants negatively affected the antiviral activity of these DAAs, and that mycophenolic acid has an additive effect on their antiviral action.
Publish Date	2018-09-07 06:15
Citation	de Ruiter PE, Gadjradj Y, de Knegt R, Metselaar HJ, Ijzermans JNM, van der Laan LJW. Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid. World J Transplant 2018; 8(5): 156-166
URL	http://www.wjgnet.com/2220-3230/full/v8/i5/156.htm
DOI	http://dx.doi.org/10.5500/wjt.v8.i5.156

Full Article (PDF)	WJT-8-156.pdf
Manuscript File	39055-Review.docx
Answering Reviewers	39055-Answering reviewers.pdf
Audio Core Tip	39055-Audio core tip.wav
Biostatistics Review Certificate	39055-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39055-Conflict-of-interest statement.pdf
Copyright License Agreement	39055-Copyright assignment.pdf
Peer-review Report	39055-Peer-review(s).pdf
Scientific Misconduct Check	39055-Scientific misconduct check.pdf
Scientific Editor Work List	39055-Scientific editor work list.pdf