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10/19/2018 4:29:42 AM | Browse: 654 | Download: 860
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Received |
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2018-05-07 00:29 |
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Peer-Review Started |
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2018-05-07 01:48 |
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To Make the First Decision |
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2018-06-15 02:20 |
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Return for Revision |
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2018-06-19 00:47 |
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Revised |
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2018-06-20 20:01 |
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Second Decision |
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2018-06-28 10:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-06-28 23:46 |
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Articles in Press |
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2018-06-28 23:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-07-08 02:14 |
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Typeset the Manuscript |
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2018-10-13 11:25 |
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Publish the Manuscript Online |
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2018-10-18 11:08 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Dose of alendronate directly increases trabeculae expansivity without altering bone volume in rat femurs
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Suyany G Weiss, Gabrielle O Kuchar, Jennifer T Gerber, Fernanda Tiboni, Carmen Lucia M Storrer, Thaís C Casagrande, Allan F Giovanini and Rafaela Scariot |
| Funding Agency and Grant Number |
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| Corresponding Author |
Rafaela Scariot, PhD, Associate Professor, School of Health Science, Department of Dentistry, Positivo University, 5300 Professor Pedro Viriato Parigot de Souza Street, Campo Comprido, Curitiba, Paraná 81280-330, Brazil. rafaela.moraes@up.edu.br |
| Key Words |
Alendronate; Bone regeneration; Fracture; Femur; Bisphosphonates |
| Core Tip |
Several studies have been carried out to determine both the influence of alendronate in bone repair and the appropriate dose of this drug to promote bone regeneration. In this research, 36 Wistar rats were allocated into three distinct groups that received applications of either alendronate at different doses or saline solution three times a week for 45 d. The rats underwent femoral fracture surgery with stable internal fixation. The imaginologic results suggested that the use of alendronate did not have a direct influence on the amount of bone neoformation, however it did influence bone quality in a dose-dependent manner. |
| Publish Date |
2018-10-18 11:08 |
| Citation |
Weiss SG, Kuchar GO, Gerber JT, Tiboni F, Storrer CLM, Casagrande TC, Giovanini AF, Scariot R. Dose of alendronate directly increases trabeculae expansivity without altering bone volume in rat femurs. World J Orthop 2018; 9(10): 190-197 |
| URL |
http://www.wjgnet.com/2218-5836/full/v9/i10/190.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v9.i10.190 |
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