BPG is committed to discovery and dissemination of knowledge
Featured Articles
9/20/2018 7:58:59 AM | Browse: 477 | Download: 578
Publication Name World Journal of Gastroenterology
Manuscript ID 39634
Country/Territory Spain
Received
2018-05-03 10:32
Peer-Review Started
2018-05-04 06:47
To Make the First Decision
2018-05-17 02:55
Return for Revision
2018-05-21 07:51
Revised
2018-06-28 19:13
Second Decision
2018-07-13 09:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-07-16 01:50
Articles in Press
2018-07-16 01:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-08-31 09:11
Publish the Manuscript Online
2018-09-06 01:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
Manuscript Source Invited Manuscript
All Author List Javier A García-Vilas and Miguel Ángel Medina
Funding Agency and Grant Number
Funding Agency Grant Number
MINECO and FEDER BIO2014-56092-R
Andalusian Government and FEDER P12-CTS-1507
Andalusian Government BIO-267
Corresponding Author Miguel Ángel Medina, PhD, Full Professor, Department of Molecular Biology and Biochemistry, University of Málaga, Department of Molecular Biology and Biochemistry Faculty of Sciences, University of Malaga , Boulevar Louis Pasteur 31, Málaga 29071, Spain. medina@uma.es
Key Words Hepatocellular carcinoma; Hepatocyte growth factor/c-MET; Tumor microenvironment; c-Met canonical and non-canonical pathways
Core Tip Hepatocellular carcinoma (HCC) is a tumor usually arising from previous hepatic diseases as cirrhosis and chronic hepatitis B and C infections. Several studies have shown that a key factor for HCC oncogenesis is chronic inflammation. Inflammation induces changes in the gene expression pattern in surrounding cells. These changes provide an environment with a high level of cytokines, promoting hepatocyte transforma­tion to tumor cells. New therapies against HCC are focused on regulating stromal cells within the tumor microenvironment to avoid HCC progression.
Publish Date 2018-09-06 01:33
Citation García-Vilas JA, Medina MÁ. Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications. World J Gastroenterol 2018; 24(33): 3695-3708
URL http://www.wjgnet.com/1007-9327/full/v24/i33/3695.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i33.3695
Full Article (PDF) WJG-24-3695.pdf
Full Article (Word) WJG-24-3695.doc
Manuscript File 39634-Review.doc
Answering Reviewers 39634-Answering reviewers.pdf
Audio Core Tip 39634-Audio core tip.wav
Conflict-of-Interest Disclosure Form 39634-Conflict-of-interest statement.pdf
Copyright License Agreement 39634-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 39634-Language certificate.pdf
Peer-review Report 39634-Peer-review(s).pdf
Scientific Misconduct Check 39634-Scientific misconduct check.pdf
Scientific Editor Work List 39634-Scientific editor work list.pdf