Publication Name	World Journal of Stem Cells
Manuscript ID	46667
Country	Sweden

Received	2019-03-12 06:34
Peer-Review Started	2019-03-15 00:16
To Make the First Decision	2019-06-05 06:49
Return for Revision	2019-06-06 05:58
Revised	2019-06-13 15:58
Second Decision	2019-06-19 02:43
Accepted by Journal Editor-in-Chief	2019-06-19 19:16
Accepted by Company Editor-in-Chief	2019-06-20 19:24
Articles in Press	2019-06-20 19:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-29 18:35
Typeset the Manuscript	2019-08-22 12:14
Publish the Manuscript Online	2019-08-26 10:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Bone marrow microenvironment: The guardian of leukemia stem cells
Manuscript Source	Invited Manuscript
All Author List	Mohammad Houshmand, Teresa Mortera Blanco, Paola Circosta, Narjes Yazdi, Alireza Kazemi, Giuseppe Saglio and Mahin Nikougoftar Zarif
Funding Agency and Grant Number
Corresponding Author	Mahin Nikougoftar Zarif, PhD, Associate Professor, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm 14183, Sweden. mahin.nikougoftar.zarif@ki.se
Key Words	Bone marrow microenvironment; Bone marrow niche; Leukemic stem cell; Chronic myeloid leukemia; Acute myeloid leukemia; Target therapy
Core Tip	Chronic myeloid leukemia stem cells (LSCs) and acute myeloid leukemia LSCs are resistant to common therapies due to the activation of downstream signaling pathways which guarantee their survival. Also, they are smart enough to escape from immune surveillance. Bone marrow microenvironment (BMM) is behind of all these phenomena by providing an environment which favor leukemia development. Recent studies confirm that targeting LSCs and their crosstalk with the BMM significantly reduces residual disease burden and eventuated in LSCs removal.
Publish Date	2019-08-26 10:16
Citation	Houshmand M, Mortera Blanco T, Circosta P, Yazdi N, Kazemi A, Saglio G, Nikougoftar Zarif M. Bone marrow microenvironment: The guardian of leukemia stem cells. World J Stem cells 2019; 11(8):476-490
URL	https://www.wjgnet.com/1948-0210/full/v11/i8/476.htm
DOI	https://dx.doi.org/10.4252/wjsc.v11.i8.476

Full Article (PDF)	WJSC-11-476.pdf
Full Article (Word)	WJSC-11-476.docx
Manuscript File	FP6887_de5_CE1MS-edit3.docx
Answering Reviewers	46667-Answering reviewers.pdf
Audio Core Tip	46667-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	46667-Conflict-of-interest statement.pdf
Copyright License Agreement	46667-Copyright license agreement.pdf
Peer-review Report	46667-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	46667-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	46667-Scientific misconduct check.pdf
Scientific Editor Work List	46667-Scientific editor work list.pdf