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5/28/2019 12:12:53 AM | Browse: 912 | Download: 843
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Received |
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2019-03-06 05:29 |
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Peer-Review Started |
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2019-03-07 10:31 |
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To Make the First Decision |
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2019-04-02 02:36 |
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Return for Revision |
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2019-04-11 06:12 |
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Revised |
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2019-05-15 19:26 |
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Second Decision |
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2019-05-17 07:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-05-21 18:03 |
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Articles in Press |
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2019-05-21 18:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-23 19:26 |
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Typeset the Manuscript |
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2019-05-25 07:10 |
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Publish the Manuscript Online |
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2019-05-27 08:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Alexandra Alexopoulou, Iliana Mani, Dina G Tiniakos, Flora Kontopidou, Ioanna Tsironi, Marina Noutsou, Helen Pantelidaki and Spyros P Dourakis |
| Funding Agency and Grant Number |
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| Corresponding Author |
Alexandra Alexopoulou, MD, PhD, Adjunct Professor, Associate Professor, 2nd Department of Medicine, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, 114 Vas Sophias St, Athens 11527, Greece. alexopou@ath.forthnet.gr |
| Key Words |
Paroxysmal nocturnal hemoglobinuria; Idiopathic non-cirrhotic portal hypertension; Eculizumab; Case report |
| Core Tip |
Idiopathic non-cirrhotic portal hypertension (INCPH) diagnosis is based on liver histology, the clinical signs of portal hypertension and the exclusion of chronic liver diseases in the absence of portal and hepatic venous thrombosis. We describe a patient with paroxysmal nocturnal hemoglobinuria who presented with intravascular hemolysis, jaundice and refractory ascites. Abdominal portosystemic collaterals were evident in imaging without varices in endoscopy. Liver histology demonstrated portal venopathy, features of nodular regenerative hyperplasia and ischemic parenchymal changes without cirrhosis, all indicative of INCPH. Eculizumab treatment achieved improvement of hemolysis and reversion of biochemical and clinical manifestations of liver disease. |
| Publish Date |
2019-05-27 08:24 |
| Citation |
Alexopoulou A, Mani I, Tiniakos DG, Kontopidou F, Tsironi I, Noutsou M, Pantelidaki H, Dourakis SP. Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report. World J Hepatol 2019; 11(5): 483-488 |
| URL |
https://www.wjgnet.com/1948-5182/full/v11/i5/483.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v11.i5.483 |
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