Publication Name	World Journal of Gastroenterology
Manuscript ID	47401
Country	Türkiye

Received	2019-03-20 01:46
Peer-Review Started	2019-03-20 06:47
To Make the First Decision	2019-04-08 00:44
Return for Revision	2019-04-08 07:11
Revised	2019-04-26 08:16
Second Decision	2019-05-08 08:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-08 16:06
Articles in Press	2019-05-08 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-19 03:53
Publish the Manuscript Online	2019-06-21 03:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Alaattin Sen and Holger Stark
Funding Agency and Grant Number
Corresponding Author	Alaattin Sen, PhD, Academic Fellow, Academic Research, Chairman, Full Professor, Instructor, Professor, Research Scientist, Senior Lecturer, Senior Researcher, Senior Scientist, Department of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, Abdullah Gul University, Sumer Campus, Kocasinan, Kayseri 38080, Türkiye. sena@agu.edu.tr
Key Words	Cytochrome P450; Polymorphism; Function; Ulcerative colitis; Aetiology
Core Tip	The role of cytochrome P450s (CYPs) genes in the pathogenesis of ulcerative colitis (UC). Extrahepatic and extrarenal CYPs (e.g., macrophages and dendritic cells of colonic mucosa) have a critical role in UC development. Polymorphisms discussed can result in dysregulation of these enzymes in favour of alternative pathways producing more reactive metabolites. Production of reactive metabolites is favouring more severe disease states. Pharmacogenetics might facilitate individualized medicine for UC in the future although actually available data is limited.
Publish Date	2019-06-21 03:42
Citation	Sen A, Stark H. Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World J Gastroenterol 2019; 25(23): 2846-2862
URL	https://www.wjgnet.com/1007-9327/full/v25/i23/2846.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i23.2846

Full Article (PDF)	WJG-25-2846.pdf
Full Article (Word)	WJG-25-2846.docx
Manuscript File	47401-Review.docx
Answering Reviewers	47401-Answering reviewers.pdf
Audio Core Tip	47401-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	47401-Conflict-of-interest statement.pdf
Copyright License Agreement	47401-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	47401-Language certificate.pdf
Peer-review Report	47401-Peer-review(s).pdf
Scientific Misconduct Check	47401-Google-MA RY-1.png
Scientific Misconduct Check	47401-Google-MA RY-2.png
Scientific Misconduct Check	47401-Scientific misconduct check.pdf
Scientific Editor Work List	47401-Scientific editor work list.pdf