| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Improved method for inducing chronic atrophic gastritis in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian Wei, Xue-Ping Feng, Lu-Yao Wang, Yan-Qiang Huang, Lin-Ling Liang, Xiao-Qiang Mo and Hong-Yu Wei |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31460023 |
| Science Research and Technology Development Project of Guangxi |
1598025-33 |
|
| Corresponding Author |
Yan-Qiang Huang, MD, PhD, Academic Research, Chief Doctor, N/A, Pharmacist, Reader (Associate Professor), Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical College for Nationalities, No. 98 Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China, Baise 533000, China. huangyanqiang120@163.com |
| Key Words |
Method; Chronic atrophic gastritis; Mice; Helicobacter pylori; N-methyl-N'-nitroguanidine; Ammonia water |
| Core Tip |
The chronic atrophic gastritis (CAG) model was successfully established at the 90th day after the last Helicobacter pylori (Hp) infection of six-week-old mice, with a success rate reaching 90%. The method overcomes the difficulty in colonising Hp in mice and the fact that the colonisation time is short. In addition, rats are replaced with mice, and the method is thus simpler and also cheaper. The established models are stable and safe, therefore, the method is a relatively ideal method for establishing a mice model of CAG. It provides a significant helping when exploring the mechanisms of occurrence, and prevention CAG. |
| Publish Date |
2019-12-10 02:02 |
| Citation |
Wei X, Feng XP, Wang LY, Huang YQ, Liang LL, Mo XQ, Wei HY. Method for constructing chronic atrophic gastritis in mice. World J Gastrointest Oncol 2019; 11(12): 1115-1125 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i12/1115.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i12.1115 |
