Publication Name	World Journal of Gastroenterology
Manuscript ID	48781
Country	United States

Received	2019-05-05 01:39
Peer-Review Started	2019-05-05 07:58
To Make the First Decision	2019-06-10 08:23
Return for Revision	2019-06-14 00:34
Revised	2019-07-26 22:48
Second Decision	2019-08-30 11:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-28 04:50
Articles in Press	2019-09-28 04:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-14 07:44
Publish the Manuscript Online	2019-10-14 10:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of ion channels in gastrointestinal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Kyle J Anderson, Robert T Cormier and Patricia M Scott
Funding Agency and Grant Number
Corresponding Author	Patricia M Scott, PhD, Assistant Professor, Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, United States. pscott@d.umn.edu
Key Words	Ion channels; Gastrointestinal cancer; Colorectal cancer; Gastric cancer; Pancreatic cancer; Esophageal cancer
Core Tip	Ion channels play an essential function in the physiology of the GI tract. There is increasing evidence that they are dysregulated at all stages of gastrointestinal (GI) cancer, from early initiation to metastasis. This information provides for the use of ion channel expression as useful clinical prognostic biomarkers in GI cancer. Perhaps more importantly new therapeutic modalities targeting ion channels in the GI tract, including the potential to target their dysregulation in GI cancers are becoming increasingly feasible. This strategy includes the repurposing of existing drugs that are used to treat other ion channel pathologies, or other diseases altogether. This review seeks to provide an overview of the role of ion channels in GI cancers with an emphasis on the potential for new therapies that target them.
Publish Date	2019-10-14 10:47
Citation	Anderson KJ, Cormier RT, Scott PM. Role of ion channels in gastrointestinal cancer. World J Gastroenterol 2019; 25(38): 5732-5772
URL	https://www.wjgnet.com/1007-9327/full/v25/i38/5732.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i38.5732

Full Article (PDF)	WJG-25-5732.pdf
Full Article (Word)	WJG-25-5732.docx
Manuscript File	48781-Review.docx
Answering Reviewers	48781-Answering reviewers.pdf
Audio Core Tip	48781-Audio core tip.aif
Conflict-of-Interest Disclosure Form	48781-Conflict-of-interest statement.pdf
Copyright License Agreement	48781-Copyright license agreement.pdf
Peer-review Report	48781-Peer-review(s).pdf
Scientific Misconduct Check	48781-Scientific misconduct check.pdf
Scientific Editor Work List	48781-Scientific editor work list.pdf