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11/15/2019 9:24:27 AM | Browse: 511 | Download: 639
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Received |
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2019-05-25 06:23 |
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Peer-Review Started |
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2019-05-27 00:52 |
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To Make the First Decision |
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2019-08-06 02:52 |
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Return for Revision |
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2019-08-28 07:22 |
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Revised |
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2019-09-02 10:24 |
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Second Decision |
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2019-09-12 10:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-09-14 15:58 |
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Articles in Press |
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2019-09-14 15:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-27 23:48 |
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Typeset the Manuscript |
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2019-10-27 10:18 |
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Publish the Manuscript Online |
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2019-11-05 08:52 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Ophthalmology |
| Manuscript Type |
Review |
| Article Title |
Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vladimir Holan, Barbora Hermankova, Magdalena Krulova and Alena Zajicova |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant Agency of the Czech Republic |
17-04800S, 18-04393S and 19-02290S |
| Ministry of Education, Youth and Sports of the Czech Republic |
SVV 244-260435, NPU-I: LO1508 and NPU-I: LO1309 |
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| Corresponding Author |
Vladimir Holan, PhD, Professor, Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 4 14220, Czech Republic. vladimir.holan@iem.cas.cz |
| Key Words |
Retina; Degenerative diseases; Stem cell therapy; Mesenchymal stem cells; Cytokines; Growth factors |
| Core Tip |
Cell-based therapy using autologous mesenchymal stem cells (MSCs) represents a perspective approach for the treatment of so far incurrable degenerative retinal diseases. However, the therapeutic potential of MSCs strongly depends on the cytokine environment, where these cells are delivered. In this study we discuss recent knowledge regarding the interactions and interplay among cytokines produced by cells of the diseased retina, inflammatory immune cells and therapeutically administered MSCs. We suggest that these interactions among cytokines and growth factors occurring in the microenvironment of the diseased retina could be critical for the outcome of the stem cell-based therapy for retinal disorders. |
| Publish Date |
2019-11-05 08:52 |
| Citation |
Holan V, Hermankova B, Krulova M, Zajicova A. Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy. World J Stem Cells 2019; 11(11):957-967 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i11/957.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i11.957 |
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