Publication Name	World Journal of Clinical Cases
Manuscript ID	50739
Country	Japan

Received	2019-09-03 09:01
Peer-Review Started	2019-09-03 09:02
To Make the First Decision	2019-10-18 01:47
Return for Revision	2019-10-18 08:57
Revised	2019-12-14 15:58
Second Decision	2019-12-19 02:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-12-22 14:27
Articles in Press	2019-12-22 14:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-30 13:46
Publish the Manuscript Online	2020-02-06 02:37

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Engineering, Biomedical
Manuscript Type	Clinical and Translational Research
Article Title	Novel zinc alloys for biodegradable surgical staples
Manuscript Source	Unsolicited Manuscript
All Author List	Hizuru Amano, Koichi Miyake, Akinari Hinoki, Kazuki Yokota, Fumie Kinoshita, Atsuko Nakazawa, Yujiro Tanaka, Yasuhiro Seto and Hiroo Uchida
Funding Agency and Grant Number
Corresponding Author	Hiroo Uchida, MD, PhD, Doctor, Professor, Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Syowa-ku, Nagoya 4668550, Aichi, Japan. hiro2013@med.nagoya-u.ac.jp
Key Words	Zinc alloy; Surgical staple; Gastric resection; Biodegradability; Biocompatibility; Mechanical strength
Core Tip	Biodegradable Zn alloy can be prepared with adequate strength, ductility, biodegradability, and biocompatibility for use as surgical staples by alloying with ≤1 wt.% Mn or Cu and 0.1 wt.% Ti. Immersion tests reveal no gas evolution or staple fracture. In vivo, none of the Zn alloy staples cause technical failure, and all rabbits survive without complications. The degradation times are sufficient for wound healing. The degradation rate is increased under low pH conditions, suggesting staples used for resection or anastomosis of gastrointestinal tracts would degrade faster, as they are exposed to acidic digestive fluids.
Publish Date	2020-02-06 02:37
Citation	Amano H, Miyake K, Hinoki A, Yokota K, Kinoshita F, Nakazawa A, Tanaka Y, Seto Y, Uchida H. Novel zinc alloys for biodegradable surgical staples. World J Clin Cases 2020; 8(3): 504-516
URL	https://www.wjgnet.com/2307-8960/full/v8/i3/504.htm
DOI	https://dx.doi.org/10.12998/wjcc.v8.i3.504

Full Article (PDF)	WJCC-8-504.pdf
Full Article (Word)	WJCC-8-504.docx
Manuscript File	50739-Review.docx
Answering Reviewers	50739-Answering reviewers.pdf
Audio Core Tip	50739-Audio core tip.mp3
Biostatistics Review Certificate	50739-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	50739-Conflict-of-interest statement.pdf
Copyright License Agreement	50739-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	50739-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	50739-Language certificate.pdf
Peer-review Report	50739-Peer-review(s).pdf
Scientific Misconduct Check	50739-Scientific misconduct check.pdf
Scientific Editor Work List	50739-Scientific editor work list.pdf