Publication Name	World Journal of Stem Cells
Manuscript ID	52909
Country	China

Received	2019-12-18 06:44
Peer-Review Started	2019-12-18 06:48
To Make the First Decision
Return for Revision	2020-02-20 05:30
Revised	2020-03-17 06:18
Second Decision	2020-04-08 13:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-09 00:31
Articles in Press	2020-04-09 00:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-04-19 23:08
Typeset the Manuscript	2020-05-25 10:05
Publish the Manuscript Online	2020-06-25 10:09

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Hao Lei, Wen Yan, Chun-Hua Luo, Yu-Ming Guo, Yang-Yang Zhang, Xing-Huan Wang and Xin-Jun Su
Funding Agency and Grant Number	Funding Agency Grant Number Health and Family Planning Committee Joint Fund Project of Hubei Province WJ2018H0020 Fundamental Research Funds for the Central Universities 2042016kf0187 Health and Family Planning Committee Joint Fund Project of Hubei Province 2042017kf0068 Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund znpy2016022
Corresponding Author	Xin-Jun Su, MA, Chief Doctor, Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, Donghu Road No. 169, Wuhan 430071, Hubei Province, China. 13697326659@139.com
Key Words	Spermatogonial stem cells; Nonylphenol; Cytotoxicity; Phosphatidylinositol-3-kinase; Protein kinase B; Mammalian target of rapamycin
Core Tip	With continuous advancement of industrial society, environmental pollution has become more and more serious, there has been an increase in infertility caused by environmental factors. Nonylphenol is a stable degradation product widely used in daily life and production and has been proven to affect male fertility. Our study demonstrated that nonylphenol reduced the proliferation, differentiation, and stemness maintenance of spermatogonial stem cells while promoting apoptosis and oxidative stress, and the mechanism may be related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway, providing a potential method for the treatment of male infertility.
Publish Date	2020-06-25 10:09
Citation	Lei JH, Yan W, Luo CH, Guo YM, Zhang YY, Wang XH, Su XJ. Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway. World J Stem Cells 2020; 12(6): 500-513
URL	https://www.wjgnet.com/1948-0210/full/v12/i6/500.htm
DOI	https://dx.doi.org/10.4252/wjsc.v12.i6.500

Full Article (PDF)	WJSC-12-500.pdf
Full Article (Word)	WJSC-12-500.docx
Manuscript File	52909-Review_Filipodia.docx
Answering Reviewers	52909-Answering reviewers.pdf
Audio Core Tip	52909-Audio core tip.mp3
Biostatistics Review Certificate	52909-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	52909-Conflict-of-interest statement.pdf
Copyright License Agreement	52909-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	52909-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	52909-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	52909-Language certificate.pdf
Peer-review Report	52909-Peer-review(s).pdf
Scientific Misconduct Check	52909-Scientific misconduct check.pdf
Scientific Editor Work List	52909-Scientific editor work list.pdf