| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bi-Xia Huang, Yan Liu, Zhen-Ping Fan, Lan-Lan Si, Rong-Juan Chen, Jun Wang, Dan Luo, Fu-Sheng Wang, Dong-Ping Xu and Xin-Guang Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81572010 |
| the National Natural Science Foundation of China |
81671399 |
| the National Natural Science Foundation of China |
81721002 |
| the National Natural Science Foundation of China |
81971329 |
| the Capital Health Research and Development of Special Fund Program |
2016-2-5032 |
| Beijing Natural Science Foundation |
7172206 |
|
| Corresponding Author |
Dong-Ping Xu, MD, PhD, Professor, Institute of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, 100, Xisihuan Middle Road, Beijing 100039, China. xudongping302@sina.com |
| Key Words |
Hepatitis B virus; Immune escape-associated mutation; Drug-resistance mutation; Nucleoside/nucleotide analogs; Hepatitis B surface antigen; The major hydrophilic region |
| Core Tip |
A large number of patients were surveyed for immune escape-associated mutations, and the link between immune escape-associated and resistant mutations was identified. Contribution of sA159V to resistance was found in multiple followed-up patients, especially sA159V reduced hepatitis B surface antigen but raised replication capacity of lamivudine/entecavir-resistant mutants. |
| Publish Date |
2020-09-17 01:56 |
| Citation |
Huang BX, Liu Y, Fan ZP, Si LL, Chen RJ, Wang J, Luo D, Wang FS, Xu DP, Liu XG. Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations. World J Gastroenterol 2020; 26(35): 5314-5327 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i35/5314.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i35.5314 |
