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Publication Name World Journal of Clinical Oncology
Manuscript ID 56848
Country/Territory Brazil
Received
2020-05-16 19:34
Peer-Review Started
2020-05-16 19:35
To Make the First Decision
Return for Revision
2020-06-06 12:05
Revised
2020-06-06 15:39
Second Decision
2020-08-25 08:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-26 04:45
Articles in Press
2020-08-26 04:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-28 18:06
Typeset the Manuscript
2020-09-15 13:33
Publish the Manuscript Online
2020-09-19 03:49
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Diacerein treatment prevents colitis-associated cancer in mice
Manuscript Source Unsolicited Manuscript
All Author List Daiane S M Paulino, Maria Carolina S Mendes, Juliana A Camargo, Sandra R Brambilla, Tanila Wood Dos Santos, Marcelo L Ribeiro and José Barreto Campello Carvalheira
Funding Agency and Grant Number
Funding Agency Grant Number
São Paulo Research Foundation 07607-8/2013
National Research Council 150127/2016-2
National Research Council 306821/2010-9
Corresponding Author José Barreto Campello Carvalheira, MD, PhD, Associate Professor, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Tessália Vieira Camargo, S/N, Sao Paulo 13083-970, Brazil. jbcc@unicamp.br
Key Words Colon cancer; Cancer stem cell; Chemoprevention; ; ;
Core Tip Inflammation is a well-established factor for colitis-associated cancer (CAC) development. In accordance, chronic inflammation has been implicated in cancer stem cells (CSCs) development. The present study evaluates the role of diacerein (DAR), an anti-inflammatory drug, in the development of an experimental model of CSCs and CAC. DAR treatment reduced colon inflammation, number and size of tumors. DAR treatment was associated with reduced intracellular signals of inflammation (inhibitor of nuclear factor kappa B kinase and c-Jun N-terminal kinase phosphorylation) in colon. DAR treatment was associated with a decrease in colon CSC formation, suggesting that besides reducing colonic inflammation, DAR has a direct effect on the inhibition of colon carcinogenesis.
Publish Date 2020-09-19 03:49
Citation Paulino DSM, Mendes MCS, Camargo JA, Brambilla SR, Wood Dos Santos T, Ribeiro ML, Carvalheira JBC. Diacerein treatment prevents colitis-associated cancer in mice. World J Clin Oncol 2020; 11(9): 732-746
URL https://www.wjgnet.com/2218-4333/full/v11/i9/732.htm
DOI https://dx.doi.org/10.5306/wjco.v11.i9.732
Full Article (PDF) WJCO-11-732.pdf
Full Article (Word) WJCO-11-732.docx
The ARRIVE Guidelines 56848-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 56848-Review-Filipodia.docx
Answering Reviewers 56848-Answering reviewers.pdf
Audio Core Tip 56848-Audio core tip.ogg
Biostatistics Review Certificate 56848-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 56848-Conflict-of-interest statement.pdf
Copyright License Agreement 56848-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56848-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 56848-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 56848-Language certificate.pdf
Supplementary Material 56848-Supplementary material.pdf
Peer-review Report 56848-Peer-review(s).pdf
Scientific Misconduct Check 56848-Scientific misconduct check.pdf
Scientific Editor Work List 56848-Scientific editor work list.pdf