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11/12/2020 4:09:15 AM | Browse: 551 | Download: 585
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Received |
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2020-06-09 06:46 |
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Peer-Review Started |
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2020-06-09 06:47 |
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To Make the First Decision |
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Return for Revision |
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2020-07-04 21:40 |
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Revised |
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2020-07-15 08:38 |
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Second Decision |
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2020-09-17 13:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-09-18 20:23 |
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Articles in Press |
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2020-09-18 20:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-10-07 03:26 |
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Typeset the Manuscript |
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2020-11-09 15:19 |
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Publish the Manuscript Online |
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2020-11-12 03:59 |
ISSN |
1948-5204 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Meta-Analysis |
Article Title |
Efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in treatment of advanced gastric cancer or gastroesophageal junction cancer: A meta-analysis
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Li Yang, Xian-Zhe Dong, Xiao-Xuan Xing, Xiao-Hui Cui, Lin Li and Lan Zhang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Beijing Hospitals Authority Ascent Plan |
DFL20190803 |
Capital Science and Technology Leading Talent Training Project |
Z191100006119017 |
National Nature and Science Foundation of China |
81773778 |
China Postdoctoral Science Foundation |
2019M650775 |
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Corresponding Author |
Lan Zhang, PhD, Professor, Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. lanizhg@126.com |
Key Words |
Gastric cancer; Gastroesophageal junction cancer; Anti-PD-1/anti-PD-L1 antibody therapy; Meta-analysis; Systematic review; |
Core Tip |
Anti-PD-1/anti-PD-L1 antibody therapy, such as nivolumab and pembrolizumab, which has been approved by the FDA for marketing, enhances the body′s cellular immune response to anti-tumor effects by regulating T cell function. At present, it has become the first-line treatment for extensive stage small cell lung cancer and other cancers. In recent years, some clinical trials have also shown that anti-PD-1/anti-PD-L1 antibody therapy has a reliable effect in advanced gastric cancer or gastroesophageal junction cancer (GC/GEJC) patients, but there is still controversy. The main purpose of this review is to comprehensively evaluate the efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in treatment of advanced GC/GEJC patients. |
Publish Date |
2020-11-12 03:59 |
Citation |
Yang L, Dong XZ, Xing XX, Cui XH, Li L, Zhang L. Efficacy and safety of anti-PD-1/anti-PD-L1 antibody therapy in treatment of advanced gastric cancer or gastroesophageal junction cancer: A meta-analysis. World J Gastrointest Oncol 2020; 12(11): 1346-1363 |
URL |
https://www.wjgnet.com/1948-5204/full/v12/i11/1346.htm |
DOI |
https://dx.doi.org/10.4251/wjgo.v12.i11.1346 |
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