Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	62058
Country	Ireland

Received	2020-12-27 16:40
Peer-Review Started	2020-12-27 17:00
To Make the First Decision
Return for Revision	2021-02-14 06:38
Revised	2021-02-24 22:51
Second Decision	2021-04-06 08:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 14:20
Articles in Press	2021-04-14 14:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-25 04:00
Publish the Manuscript Online	2021-05-07 09:15

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Review
Article Title	Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers
Manuscript Source	Invited Manuscript
All Author List	Ross King, Conall Hayes, Claire L Donohoe, Margaret R Dunne, Maria Davern and Noel E Donlon
Funding Agency and Grant Number
Corresponding Author	Noel E Donlon, BM BCh, Surgical Oncologist, Department of Surgery, St. James’s Hospital Campus, Trinity Translational Medicine Institute, James Street, Dublin D8, Ireland. donlonn@tcd.ie
Key Words	Esophageal cancer; Gastric cancer; Tumor hypoxia; Tumour microenvironment; Gastroesophageal cancer
Core Tip	Improved methods in measuring the oxygen status in the tumour microenvironment have allowed for a better understanding of the role of hypoxia and how it contributes to tumour progression and treatment resistance. These methods include non-invasive imaging techniques as well as validated hypoxic molecular signatures. Specific hypoxia-targeted therapies have not lived up to their expectations but may have potential application in combination with traditional treatment approaches in gastroesophageal cancer.
Publish Date	2021-05-07 09:15
Citation	King R, Hayes C, Donohoe CL, Dunne MR, Davern M, Donlon NE. Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers. World J Gastrointest Oncol 2021; 13(5): 312-331
URL	https://www.wjgnet.com/1948-5204/full/v13/i5/312.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i5.312

Full Article (PDF)	WJGO-13-312.pdf
Full Article (Word)	WJGO-13-312.docx
Manuscript File	62058_Auto_Edited_LM.docx
Answering Reviewers	62058-Answering reviewers.pdf
Audio Core Tip	62058-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	62058-Conflict-of-interest statement.pdf
Copyright License Agreement	62058-Copyright license agreement.pdf
Peer-review Report	62058-Peer-review(s).pdf
Scientific Misconduct Check	62058-Bing-Yan JP-1.jpg
Scientific Misconduct Check	62058-Scientific misconduct check.pdf
Scientific Editor Work List	62058-Scientific editor work list.pdf