Publication Name	World Journal of Clinical Cases
Manuscript ID	62967
Country	China

Received	2021-01-31 04:29
Peer-Review Started	2021-01-31 04:41
To Make the First Decision
Return for Revision	2021-07-16 03:27
Revised	2021-07-19 14:45
Second Decision	2021-12-08 07:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-10 03:00
Articles in Press	2021-12-10 03:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-31 03:57
Publish the Manuscript Online	2022-01-12 04:01

ISSN	2307-8960 (online)
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Novel compound heterozygous GPR56 gene mutation in a twin with lissencephaly: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Xin Lin, Ying-Ying Chai, Ting-Ting Huang, Xia Zhang, Guo Zheng, Gang Zhang, Fang Peng and Yanjun Huang
Funding Agency and Grant Number	Funding Agency Grant Number Six Talent Peaks Project in Jiangsu Province 2016-YY-055
Corresponding Author	Yanjun Huang, PhD, Additional Professor, Chief Physician, Department of Neurology, Children’s Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing 210000, JiangSu, China. njhuang2013@126.com
Key Words	Lissencephaly; Epilepsy; GPR56 mutations; Compound heterozygous mutations; Case report
Core Tip	We report a twin infant with lissencephaly (LIS). The twins both carried the novel compound heterozygous GPR56 mutations, p.F76fs and p.H607fs, which have not been reported in the Human Gene Mutation Database. To our knowledge, this is the first case of GRP56-related LIS. Therefore, GPR56 gene mutations may lead to LIS.
Publish Date	2022-01-12 04:01
Citation	Lin WX, Chai YY, Huang TT, Zhang X, Zheng G, Zhang G, Peng F, Huang YJ. Novel compound heterozygous GPR56 gene mutation in a twin with lissencephaly: A case report. World J Clin Cases 2022; 10(2): 607-617
URL	https://www.wjgnet.com/2307-8960/full/v10/i2/607.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i2.607

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