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7/21/2021 9:37:44 AM | Browse: 320 | Download: 639
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Received |
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2021-02-03 15:15 |
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Peer-Review Started |
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2021-02-03 15:16 |
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To Make the First Decision |
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Return for Revision |
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2021-03-31 04:59 |
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Revised |
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2021-04-04 12:47 |
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Second Decision |
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2021-06-03 08:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-06-03 12:02 |
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Articles in Press |
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2021-06-03 12:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-13 21:00 |
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Typeset the Manuscript |
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2021-07-20 04:42 |
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Publish the Manuscript Online |
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2021-07-21 09:30 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Evgeny Imyanitov and Anna Sokolenko |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Higher Education of the Russian Federation |
15-2020-789 |
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| Corresponding Author |
Evgeny Imyanitov, MD, Professor, Department of Tumor Growth Biology, N.N. Petrov Institute of Oncology, Pesochny, Leningradskaya str. 68, Saint-Petersburg 197758, Russia. evgeny@imyanitov.spb.ru |
| Key Words |
BRCA1/2 mutations; platinum-based therapy; Poly (ADP-ribose) polymerase inhibitors; drug resistance; Secondary mutations; Intratumoral heterogeneity; Neoadjuvant therapy |
| Core Tip |
BRCA1/2-associated tumors are highly sensitive to platinum compounds and poly (ADP-ribose) polymerase inhibitors, however they eventually acquire resistance to this type of therapy. Restoration of BRCA1/2 function via the second mutation is the most known mechanism of tumor adaptation to the therapeutic pressure. Some studies demonstrate that even chemonaive BRCA1-driven tumors contain a small fraction of BRCA1-proficient cells, suggesting that the loss of the remaining allele of this gene is not the first event in tumor pathogenesis. These pre-existing platinum-resistant cells rapidly repopulate tumor mass during neoadjuvant therapy for ovarian cancer and explain inevitability of the disease relapses after seemingly successful surgical debulking. |
| Publish Date |
2021-07-21 09:30 |
| Citation |
Imyanitov E, Sokolenko A. Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors. World J Clin Oncol 2021; 12(7): 544-556 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i7/544.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i7.544 |
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