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7/23/2021 1:41:09 PM | Browse: 253 | Download: 572
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Received |
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2021-03-08 20:51 |
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Peer-Review Started |
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2021-03-08 21:02 |
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To Make the First Decision |
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Return for Revision |
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2021-03-29 23:34 |
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Revised |
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2021-04-19 02:48 |
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Second Decision |
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2021-07-05 12:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-07-05 14:18 |
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Articles in Press |
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2021-07-05 14:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-07-21 12:32 |
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Publish the Manuscript Online |
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2021-07-23 13:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Reporter gene systems for the identification and characterization of cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nohemí Salinas-Jazmín, Arely Rosas-Cruz and Marco Velasco-Velazquez |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| UNAM-PAPIIT |
IN219719 |
| UNAM-PAPIIT |
IA205421 |
| CONACYT |
A1-S-18285 |
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| Corresponding Author |
Marco Velasco-Velazquez, PhD, Professor, Department of Pharmacology, School of Medicine, Universidad Nacional Autónoma de México, Av. Universidad 3000. Cd. Universitaria. , Mexico City 04510, Mexico. marcovelasco@unam.mx |
| Key Words |
Cancer; Gene reporter systems; Cancer stem cells; Pluripotency transcription factors; Anticancer drugs; Preclinical analysis; Cancer stem cells marker |
| Core Tip |
Controversial cancer stem cells (CSCs) research has caused confusion in this discipline. CSCs should be analyzed based on their function with regard to their ability to generate serially transplantable tumors. However, such evaluations are expensive and time-consuming and are fraught with ethical issues. Gene reporter assays can be used as a surrogate measure of the presence of CSCs in a sample. When combined with immunophenotyping and functional assays, reporter systems improve the quality of the evidence. However, there is no standard system; thus, the selection of an appropriate system must carefully consider its utility in previous works for the tumor type that is to be analyzed. |
| Publish Date |
2021-07-23 13:30 |
| Citation |
Salinas-Jazmín N, Rosas-Cruz A, Velasco-Velazquez M. Reporter gene systems for the identification and characterization of cancer stem cells. World J Stem Cells 2021; 13(7): 861-876 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i7/861.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i7.861 |
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