Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	65503
Country	Japan

Received	2021-03-08 12:47
Peer-Review Started	2021-03-08 12:52
To Make the First Decision
Return for Revision	2021-05-03 11:29
Revised	2021-05-23 02:30
Second Decision	2021-11-08 03:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-15 07:26
Articles in Press	2021-11-15 07:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-30 21:36
Typeset the Manuscript	2021-12-31 03:28
Publish the Manuscript Online	2022-01-18 02:25

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Review
Article Title	Current treatment strategies and future perspectives for gastrointestinal stromal tumors
Manuscript Source	Invited Manuscript
All Author List	Sugiyama Yoichi, Masaru Sassaki, Mohei Kouyama, Tatsuya Tazaki, Shinya Takahashi and Atsushi Nakamitsu
Funding Agency and Grant Number
Corresponding Author	Sugiyama Yoichi, MD, PhD, Doctor, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, JA Hiroshima General Hospital, Jigozen 1-3-3, Hatsukaichi 738-8503, Hiroshima, Japan. sugiyama0113@gmail.com
Key Words	Gastrointestinal stromal tumor; Minimally invasive surgery; Laparoscopic surgery; Imatinib; Neoadjuvant therapy; Risk assessment
Core Tip	Radical resection is the most effective treatment for gastrointestinal stromal tumors, but there are other options including minimally invasive surgery and multidisciplinary treatment, which involves the use of neoadjuvant therapy in consideration of tumor size and location. Combination with tyrosine kinase inhibitors is important for maximizing the therapeutic effect of surgery. To predict the effect, it is important to examine the presence of tumor mutations, including type, location of the mutation, and molecular subtype. We herein discuss the current treatment strategies for gastrointestinal stromal tumors and promising treatments based on clinical trials.
Publish Date	2022-01-18 02:25
Citation	Sugiyama Y, Sasaki M, Kouyama M, Tazaki T, Takahashi S, Nakamitsu A. Current treatment strategies and future perspectives for gastrointestinal stromal tumors. World J Gastrointest Pathophysiol 2022; 13(1): 15-33
URL	https://www.wjgnet.com/2150-5330/full/v13/i1/15.htm
DOI	https://dx.doi.org/10.4291/wjgp.v13.i1.15

Full Article (PDF)	WJGP-13-15.pdf
Full Article (Word)	WJGP-13-15.docx
Manuscript File	65503_Auto_Edited-YXJW-FilipodiaCL.docx
Answering Reviewers	65503-Answering reviewers.pdf
Audio Core Tip	65503-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65503-Conflict-of-interest statement.pdf
Copyright License Agreement	65503-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65503-Language certificate.pdf
Peer-review Report	65503-Peer-review(s).pdf
Scientific Misconduct Check	65503-Bing-Wu YXJ-2.png
Scientific Editor Work List	65503-Scientific editor work list.pdf