Publication Name	World Journal of Gastroenterology
Manuscript ID	73265
Country	United States

Received	2021-11-15 21:02
Peer-Review Started	2021-11-15 21:04
To Make the First Decision
Return for Revision	2021-11-22 03:28
Revised	2021-12-02 05:42
Second Decision	2022-01-11 03:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-11 19:34
Articles in Press	2022-01-11 19:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-12 04:56
Publish the Manuscript Online	2022-01-13 11:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs
Manuscript Source	Invited Manuscript
All Author List	Andrzej S Tarnawski and Amrita Ahluwalia
Funding Agency and Grant Number
Corresponding Author	Amrita Ahluwalia, PhD, Research Scientist, Research Service, Veterans Administration Long Beach Healthcare System, 5901 E, Seventh Street, Long Beach, CA 90822, United States. amrita.ahluwalia@va.gov
Key Words	Endothelial cells; Impaired endothelial function; Blood vessels; SARS-CoV-2; COVID-19; Cytokine storm
Core Tip	The coronavirus disease 2019 (COVID-19) pandemic has enormous health care and economic impact on the entire world - infecting more than 250 million people in 213 countries and territories, causing death of more than 5 million (as of November 1, 2021). We comment here on some outstanding papers on COVID-19 published in World Journal of Gastroenterology and reviewed the important role of endothelium and blood vessels in COVID-19 infection. Endothelial cells and blood vessels are both the targets and a conduit for the spread of severe acute respiratory syndrome coronavirus 2 and play a critical role in COVID-19-induced tissue injury and dissemination to various organs. Pre-existing endothelial impaired function could make endothelial cells more sensitive to COVID-19 or at least COVID-19-induced impairment might be synergistic with pre-existing impairment. That could be one contributing factor explaining why older or diabetic patients have more severe responses to infection, since these conditions are already impacted impaired endothelial function.
Publish Date	2022-01-13 11:55
Citation	Tarnawski AS, Ahluwalia A. Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs. World J Gastroenterol 2022; 28(3): 275-289
URL	https://www.wjgnet.com/1007-9327/full/v28/i3/275.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i3.275

Full Article (PDF)	WJG-28-275.pdf
Full Article (Word)	WJG-28-275.docx
Manuscript File	73265_Auto_Edited-V1.docx
Answering Reviewers	73265-Answering reviewers.pdf
Audio Core Tip	73265-Author core tip.m4a
Conflict-of-Interest Disclosure Form	73265-Conflict-of-interest statement.pdf
Copyright License Agreement	73265-Copyright license agreement.pdf
Peer-review Report	73265-Peer-review(s).pdf
Scientific Misconduct Check	73265-Bing-Wu YXJ-2.png
Scientific Editor Work List	73265-Scientific editor work list.pdf