Publication Name	World Journal of Gastroenterology
Manuscript ID	74896
Country	Italy

Received	2022-01-17 18:14
Peer-Review Started	2022-01-17 18:15
To Make the First Decision
Return for Revision	2022-03-08 05:55
Revised	2022-03-21 18:24
Second Decision	2022-05-16 03:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-17 02:08
Articles in Press	2022-05-17 02:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-12 20:09
Typeset the Manuscript	2022-06-14 08:31
Publish the Manuscript Online	2022-06-24 13:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Patient-derived organoids for therapy personalization in inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Marianna Lucafò, Antonella Muzzo, Martina Marcuzzi, Lorenzo Giorio, Giuliana Decorti and Gabriele Stocco
Funding Agency and Grant Number
Corresponding Author	Giuliana Decorti, MD, Associate Professor, Advanced Translational Diagnostics Laboratory, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, Trieste 34137, Italy. giuliana.decorti@burlo.trieste.it
Key Words	Inflammatory bowel disease; Organoids; Intestinal epithelium; 3D cell cultures; Personalized medicine
Core Tip	Intestinal organoids have helped to unveil knowledge about inflammatory bowel diseases pathogenesis, focusing on the genetic and epigenetic factors involved in the onset of these diseases, the altered intestinal epithelial cell (IEC) functions and the interplay between IECs and other surrounding cells, including immune cells and the intestinal bacteria. Intestinal organoids are currently being evaluated in pre-clinical studies as pharmacological tools to better understand the specific mechanisms of action of already used drugs on the IECs and to identify novel pharmacological targets and approaches.
Publish Date	2022-06-24 13:12
Citation	Lucafò M, Muzzo A, Marcuzzi M, Giorio L, Decorti G, Stocco G. Patient-derived organoids for therapy personalization in inflammatory bowel diseases. World J Gastroenterol 2022; 28(24): 2636-2653
URL	https://www.wjgnet.com/1007-9327/full/v28/i24/2636.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i24.2636

Full Article (PDF)	WJG-28-2636.pdf
Full Article (Word)	WJG-28-2636.docx
Manuscript File	74896_Auto_Edited-JRF-Filipodia-CL-LS.docx
Answering Reviewers	74896-Answering reviewers.pdf
Audio Core Tip	74896-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	74896-Conflict-of-interest statement.pdf
Copyright License Agreement	74896-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	74896-Language certificate.pdf
Peer-review Report	74896-Peer-review(s).pdf
Scientific Misconduct Check	74896-Bing-Fan JR-2.png
Scientific Editor Work List	74896-Scientific editor work list.pdf