Publication Name	World Journal of Hepatology
Manuscript ID	77490
Country	Brazil

Received	2022-05-03 01:28
Peer-Review Started	2022-05-03 01:29
To Make the First Decision
Return for Revision	2022-06-08 10:32
Revised	2022-06-27 14:23
Second Decision	2022-11-02 03:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-11-03 04:27
Articles in Press	2022-11-03 04:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-09-28 17:34
Typeset the Manuscript	2022-11-08 09:29
Publish the Manuscript Online	2022-11-24 12:34

ISSN	1948-5182 (online)
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Category	Genetics & Heredity
Manuscript Type	Minireviews
Article Title	Haemochromatosis revisited
Manuscript Source	Unsolicited Manuscript
All Author List	Aline Morgan Alvarenga, Pierre Brissot and Paulo Caleb Junior Lima Santos
Funding Agency and Grant Number
Corresponding Author	Paulo Caleb Junior Lima Santos, PhD, Adjunct Professor, Department of Pharmacology - Escola Paulista de Medicina (EPM-Unifesp), Universidade Federal de São Paulo, Adress: 03 de Maio St., 100. INFAR, 4° andar - Vila Clementino - São Paulo, SP, São Paulo 04044-020, São Paulo, Brazil. paulo.caleb@unifesp.br
Key Words	Haemochromatosis; Iron overload; HFE; Molecular diagnosis; Hepcidin
Core Tip	Haemochromatosis is a genetic disease caused by hepcidin deficiency, responsible for an increase in intestinal iron absorption. Haemochromatosis is associated with homozygosity for the HFE p.Cys282Tyr mutation. However, rare cases of haemochromatosis (non-HFE haemochromatosis) can also be caused by pathogenic variants in other genes (such as HJV, HAMP, TFR2 and SLC40A1). A working group of the International Society for the Study of Iron in Biology and Medicine (BIOIRON Society) has concluded that classification based on different molecular subtypes is difficult to be adopted in clinical practice and has proposed a new classification approaching clinical questions and molecular complexity. The aim of the present review is to provide an update on classification, pathophysiology and therapeutic recommendations.
Publish Date	2022-11-24 12:34
Citation	Alvarenga AM, Brissot P, Santos PCJ. Haemochromatosis revisited. World J Hepatol 2022; 14(11): 1931-1939
URL	https://www.wjgnet.com/1948-5182/full/v14/i11/1931.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i11.1931

Full Article (PDF)	WJH-14-1931.pdf
Full Article (Word)	WJH-14-1931.docx
Manuscript File	77490_Auto_Edited-LM.docx
Answering Reviewers	77490-Answering reviewers.pdf
Audio Core Tip	77490-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	77490-Conflict-of-interest statement.pdf
Copyright License Agreement	77490-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	77490-Language certificate.pdf
Peer-review Report	77490-Peer-review(s).pdf
Scientific Misconduct Check	77490-Bing-Wu YXJ-2.png
Scientific Editor Work List	77490-Scientific editor work list.pdf