Publication Name	World Journal of Gastroenterology
Manuscript ID	79168
Country	China

Received	2022-08-07 14:10
Peer-Review Started	2022-08-07 14:14
To Make the First Decision
Return for Revision	2022-10-20 20:45
Revised	2022-10-31 12:04
Second Decision	2022-11-10 03:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-11-10 22:04
Articles in Press	2022-11-10 22:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-11 06:14
Publish the Manuscript Online	2022-11-25 02:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Jiao Li, Hong-Zhong Gou, Yu-Lin Zhang, Xiao-Jing Song and Lei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31960236 Talent Innovation and Entrepreneurship Project of Lanzhou City 2019-RC-34 Lanzhou Cheng guan District Science and Technology Planning Project 2020SHFZ0029
Corresponding Author	Lei Zhang, Doctor, Professor, The First Clinical Medical College, Lanzhou University, Donggang Road Street, Chengguan District, Lanzhou 730000, Gansu , China. 13993181644@139.com
Key Words	Primary sclerosing cholangitis; Intestinal flora; Antibiotics; Fecal microbiota transplantation; Probiotics; Bile acids
Core Tip	Primary sclerosing cholangitis (PSC) is an autoimmune disease that currently lacks treatment. The intestinal flora comprises microorganisms that colonize the human gut and play essential roles in nutrient intake, metabolic homeostasis, immune regulation, and PSC development. Thus, the intestinal flora may be a potential therapeutic target for PSC, and many recent studies have attempted to regulate it. In this review, we have reviewed the role of the intestinal flora in PSC. We believe that our study makes a significant contribution to the literature because our paper demonstrated the great potential of the gut flora as a therapeutic target for PSC treatment.
Publish Date	2022-11-25 02:19
Citation	Li ZJ, Gou HZ, Zhang YL, Song XJ, Zhang L. Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value. World J Gastroenterol 2022; 28(44): 6213-6229
URL	https://www.wjgnet.com/1007-9327/full/v28/i44/6213.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i44.6213

Full Article (PDF)	WJG-28-6213.pdf
Full Article (Word)	WJG-28-6213.docx
Manuscript File	79168_Auto_Edited-LM.docx
Answering Reviewers	79168-Answering reviewers.pdf
Audio Core Tip	79168-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	79168-Conflict-of-interest statement.pdf
Copyright License Agreement	79168-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79168-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	79168-Language certificate.pdf
Peer-review Report	79168-Peer-review(s).pdf
Scientific Editor Work List	79168-Scientific editor work list.pdf