BPG is committed to discovery and dissemination of knowledge
Featured Articles
11/25/2022 3:53:10 AM | Browse: 175 | Download: 468
Publication Name World Journal of Gastroenterology
Manuscript ID 79678
Country/Territory Italy
Received
2022-09-02 06:06
Peer-Review Started
2022-09-02 06:09
To Make the First Decision
Return for Revision
2022-09-30 04:49
Revised
2022-09-30 16:08
Second Decision
2022-11-14 03:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-11-17 22:49
Articles in Press
2022-11-17 22:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-11-10 18:45
Typeset the Manuscript
2022-11-18 09:29
Publish the Manuscript Online
2022-11-25 02:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Virological and histological evaluation of intestinal samples in COVID-19 patients
Manuscript Source Invited Manuscript
All Author List Dajana Cuicchi, Liliana Gabrielli, Maria Lucia Tardio, Giada Rossini, Antonietta D’Errico, Pierluigi Viale, Tiziana Lazzarotto and Gilberto Poggioli
Funding Agency and Grant Number
Corresponding Author Dajana Cuicchi, MD, PhD, Surgeon, Department of Medical and Surgical Sciences, Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, Bologna 40138, Italy. dajana.cuicchi@aosp.bo.it
Key Words COVID-19; SARS-CoV-2; Intestinal infection; Intestinal samples; Intestinal tropism; Rectal samples
Core Tip The detection of viral RNA in gastrointestinal tissue samples has not been adequately investigated. In this trial, 53 rectal biopsies and 6 surgical specimens from coronavirus disease 2019 patients were analyzed, with the primary objective of detecting severe acute respiratory syndrome coronavirus-2 RNA, using real time reverse transcriptase-polymerase chain reaction, and evaluating the histological features. Viral RNA was not detectable in any of the rectal biopsies performed (0/53). Histological examination of rectal biopsies showed no enterocyte damage, but mild inflammatory infiltration. Viral RNA was detected in 2 surgical specimens of the 6 examined, both of which were from patients with active neoplastic disease. Histological examination also pointed out mild inflammatory infiltration and focal vasculitis.
Publish Date 2022-11-25 02:19
Citation Cuicchi D, Gabrielli L, Tardio ML, Rossini G, D’Errico A, Viale P, Lazzarotto T, Poggioli G. Virological and histological evaluation of intestinal samples in COVID-19 patients. World J Gastroenterol 2022; 28(44): 6282-6293
URL https://www.wjgnet.com/1007-9327/full/v28/i44/6282.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i44.6282
Full Article (PDF) WJG-28-6282.pdf
Full Article (Word) WJG-28-6282.docx
STROBE Statement 79678-STROBE-Statement-revision.pdf
Manuscript File 79678_Auto_Edited-LM.docx
Answering Reviewers 79678-Answering reviewers.pdf
Audio Core Tip 79678-Audio core tip.mp3
Biostatistics Review Certificate 79678-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 79678-Conflict-of-interest statement.pdf
Copyright License Agreement 79678-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 79678-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 79678-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 79678-Language certificate.pdf
Peer-review Report 79678-Peer-review(s).pdf
Scientific Misconduct Check 79678-Bing-Wang JJ-2.png
Scientific Editor Work List 79678-Scientific editor work list.pdf