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3/28/2023 2:11:45 PM | Browse: 142 | Download: 322
Publication Name World Journal of Gastroenterology
Manuscript ID 81658
Country/Territory United States
Received
2022-11-19 07:14
Peer-Review Started
2022-11-19 07:17
To Make the First Decision
Return for Revision
2022-12-10 08:49
Revised
2023-01-12 08:20
Second Decision
2023-03-06 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-03-14 17:59
Articles in Press
2023-03-14 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-02-22 15:32
Typeset the Manuscript
2023-03-20 09:01
Publish the Manuscript Online
2023-03-28 12:59
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title New uses for an old remedy: Digoxin as a potential treatment for steatohepatitis and other disorders
Manuscript Source Invited Manuscript
All Author List Fatima Jamshed, Farzaneh Dashti, Xinshou Ouyang, Wajahat Z Mehal and Bubu A Banini
Funding Agency and Grant Number
Funding Agency Grant Number
NIH UO1 (to Mehal WZ) 5U01AA026962-02
Corresponding Author Bubu A Banini, MD, PhD, Assistant Professor, Section of Digestive Diseases, Yale School of Medicine, 40 Temple St, Suite 1A, New Haven, CT 06510, United States. bubu.banini@yale.edu
Key Words Digoxin; Cardiac glycosides; Oxidative stress; Nonalcoholic steatohepatitis; Alcohol-associated steatohepatitis; Sterile inflammation
Core Tip Digoxin has been used primarily as a cardiac drug for treatment of arrhythmias and heart failure. Preclinical work supports the repurposing of digoxin as therapy for non-cardiac conditions, including alcohol-associated steatohepatitis, nonalcoholic steatohepatitis, obesity and metabolic disorders, autoimmune and inflammatory conditions, malignancy, and viral infections, among others. Here, we provide an overview of findings to date on the potential clinical applications of digoxin and mechanisms of action in steatohepatitis and other non-cardiac disorders. We discuss evidence on the differential action of digoxin at high vs low concentrations and identify areas of further research necessary to harness its promising multifunctional use.
Publish Date 2023-03-28 12:59
Citation Jamshed F, Dashti F, Ouyang X, Mehal WZ, Banini BA. New uses for an old remedy: Digoxin as a potential treatment for steatohepatitis and other disorders. World J Gastroenterol 2023; 29(12): 1824-1837
URL https://www.wjgnet.com/1007-9327/full/v29/i12/1824.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i12.1824
Full Article (PDF) WJG-29-1824.pdf
Full Article (Word) WJG-29-1824.docx
Manuscript File 81658_Auto_Edited-LM.docx
Answering Reviewers 81658-Answering reviewers.pdf
Audio Core Tip 81658-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 81658-Conflict-of-interest statement.pdf
Copyright License Agreement 81658-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 81658-Grant application form(s).pdf
Peer-review Report 81658-Peer-review(s).pdf
Scientific Misconduct Check 81658-Bing-Fan JR-2.png
Scientific Editor Work List 81658-Scientific editor work list.pdf