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3/24/2023 9:04:01 AM | Browse: 146 | Download: 359
Publication Name World Journal of Biological Chemistry
Manuscript ID 81730
Country/Territory United States
Received
2022-11-21 12:59
Peer-Review Started
2022-11-21 13:01
To Make the First Decision
Return for Revision
2022-12-13 10:36
Revised
2022-12-20 13:28
Second Decision
2023-02-13 04:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-02-13 08:05
Articles in Press
2023-02-13 08:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-01-31 20:30
Typeset the Manuscript
2023-02-15 08:26
Publish the Manuscript Online
2023-03-24 06:09
ISSN 1949-8454 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title Molecular genetics of early-onset colorectal cancer
Manuscript Source Invited Manuscript
All Author List Olivia Marx, Marc Mankarious and Gregory Yochum
Funding Agency and Grant Number
Corresponding Author Gregory Yochum, PhD, Associate Professor, Department of Biochemistry & Molecular Biology & Surgery, Pennsylvania State University College of Medicine, 500 University Ave, Hershey, PA 17033, United States. gsy3@psu.edu
Key Words Early-onset colorectal cancer; Later-onset colorectal cancer; Mutations; oncogenes; Molecular characteristics; Transcriptomics
Core Tip Early-onset colorectal cancer (EOCRC) has a considerably different clinical presentation and genetic profile compared with later-onset colorectal cancer. Furthermore, molecular alterations in EOCRC tumors differ in patients from separate geographical locations and distinct ethnic groups. Small human cohorts and the lack of a suitable mouse model system limit EOCRC studies, however, several actionable clinical targets and biomarkers specific to EOCRC have been identified. In this review, we discuss molecular alterations in EOCRC tumors at the DNA, RNA, and protein levels, and suggest future work to examine how these changes contribute to EOCRC pathogenesis.
Publish Date 2023-03-24 06:09
Citation Marx O, Mankarious M, Yochum G. Molecular genetics of early-onset colorectal cancer. World J Biol Chem 2023; 14(2): 13-27
URL https://www.wjgnet.com/1949-8454 /full/v14/i2/13.htm
DOI https://dx.doi.org/10.4331/wjbc.v14.i2.13
Full Article (PDF) WJBC-14-13.pdf
Full Article (Word) WJBC-14-13.docx
Manuscript File 81730_Auto_Edited-LiL-Filipodia-JLW.docx
Answering Reviewers 81730-Answering reviewers.pdf
Audio Core Tip 81730-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 81730-Conflict-of-interest statement.pdf
Copyright License Agreement 81730-Copyright license agreement.pdf
Peer-review Report 81730-Peer-review(s).pdf
Scientific Misconduct Check 81730-Bing-Li L-2.png
Scientific Editor Work List 81730-Scientific editor work list.pdf