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1/23/2025 6:19:33 AM | Browse: 93 | Download: 117
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Received |
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2024-08-19 07:03 |
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Peer-Review Started |
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2024-08-06 10:04 |
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To Make the First Decision |
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Return for Revision |
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2024-11-23 19:22 |
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Revised |
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2024-12-06 10:37 |
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Second Decision |
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2024-12-25 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-12-25 06:39 |
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Articles in Press |
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2024-12-25 06:39 |
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Publication Fee Transferred |
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2024-12-16 02:17 |
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Edit the Manuscript by Language Editor |
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2025-01-04 01:32 |
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Typeset the Manuscript |
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2025-01-16 09:38 |
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Publish the Manuscript Online |
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2025-01-23 05:47 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Wei Yang, Rui Liu and Feng Xu |
Funding Agency and Grant Number |
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Corresponding Author |
Feng Xu, MD, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. fengx2024@126.com |
Key Words |
Glial cell line-derived neurotrophic factor; Ulcerative colitis; Colonic motility; Connexin 43; Dextran sodium sulfate model |
Core Tip |
The study investigated the therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) in ameliorating impaired colonic motility in a dextran sodium sulfate-induced ulcerative colitis mouse model. The findings revealed that GDNF partially enhanced colonic transit and alleviated intestinal inflammation, with its effects reliant on connexin 43 activity. The findings identified GDNF as a promising candidate for treating abnormal colonic motility in ulcerative colitis patients, highlighting the significance of connexin 43 in its therapeutic mechanism. |
Publish Date |
2025-01-23 05:47 |
Citation |
<p>Yang W, Liu R, Xu F. Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43. <i>World J Gastroenterol</i> 2025; 31(8): 100069</p> |
URL |
https://www.wjgnet.com/1007-9327/full/v31/i8/100069.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v31.i8.100069 |
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