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1/23/2025 6:19:33 AM | Browse: 93 | Download: 117
Publication Name World Journal of Gastroenterology
Manuscript ID 100069
Country China
Received
2024-08-19 07:03
Peer-Review Started
2024-08-06 10:04
To Make the First Decision
Return for Revision
2024-11-23 19:22
Revised
2024-12-06 10:37
Second Decision
2024-12-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-12-25 06:39
Articles in Press
2024-12-25 06:39
Publication Fee Transferred
2024-12-16 02:17
Edit the Manuscript by Language Editor
2025-01-04 01:32
Typeset the Manuscript
2025-01-16 09:38
Publish the Manuscript Online
2025-01-23 05:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43
Manuscript Source Unsolicited Manuscript
All Author List Wei Yang, Rui Liu and Feng Xu
Funding Agency and Grant Number
Corresponding Author Feng Xu, MD, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. fengx2024@126.com
Key Words Glial cell line-derived neurotrophic factor; Ulcerative colitis; Colonic motility; Connexin 43; Dextran sodium sulfate model
Core Tip The study investigated the therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) in ameliorating impaired colonic motility in a dextran sodium sulfate-induced ulcerative colitis mouse model. The findings revealed that GDNF partially enhanced colonic transit and alleviated intestinal inflammation, with its effects reliant on connexin 43 activity. The findings identified GDNF as a promising candidate for treating abnormal colonic motility in ulcerative colitis patients, highlighting the significance of connexin 43 in its therapeutic mechanism.
Publish Date 2025-01-23 05:47
Citation <p>Yang W, Liu R, Xu F. Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43. <i>World J Gastroenterol</i> 2025; 31(8): 100069</p>
URL https://www.wjgnet.com/1007-9327/full/v31/i8/100069.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i8.100069
Full Article (PDF) WJG-31-100069-with-cover.pdf
The ARRIVE Guidelines 100069-The-ARRIVE-Guidelines.pdf
Manuscript File 100069-Review-Filipodia CL-fanm.docx
Answering Reviewers 100069-answering-reviewers.pdf
Audio Core Tip 100069-audio.aac
Biostatistics Review Certificate 100069-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 100069-conflict-of-interest-statement.pdf
Copyright License Agreement 100069-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 100069-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 100069-non-native-speakers.pdf
Peer-review Report 100069-peer-reviews.pdf
Scientific Misconduct Check 100069-scientific-misconduct-check.png
Scientific Editor Work List 100069-scientific-editor-work-list.pdf
CrossCheck Report 100069-crosscheck-report.png
CrossCheck Report 100069-crosscheck-report.pdf