Publication Name	World Journal of Gastroenterology
Manuscript ID	100077
Country	Mexico

Received	2024-08-06 13:30
Peer-Review Started	2024-08-06 13:30
To Make the First Decision
Return for Revision	2024-10-13 00:18
Revised	2024-10-23 00:01
Second Decision	2024-11-04 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-04 06:40
Articles in Press	2024-11-04 06:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-13 06:17
Typeset the Manuscript	2024-11-15 04:14
Publish the Manuscript Online	2024-11-29 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis
Manuscript Source	Invited Manuscript
All Author List	Bryan Adrian Priego-Parra and Jose Maria Remes-Troche
Funding Agency and Grant Number
Corresponding Author	Bryan Adrian Priego-Parra, MD, PhD, Digestive Physiology and Gastrointestinal Motility Laboratory, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdány 20 de Noviembre, Col. Centro, Veracruz 91700, Mexico. bryanpriegop@gmail.com
Key Words	Gastric cancer; Depression; Psychogastroenterology; Microbiota-gut-brain axis; Mood disorders; Dysbiosis
Core Tip	Gastrointestinal cancer and depression are intricately linked in a complex, bidirectional relationship, likely mediated by the microbiota-gut-brain axis through partially understood mechanisms. Chronic inflammation, microbiome alterations, and disruptions to intestinal and blood-brain barriers are pivotal in this interaction. Depression may emerge as a consequence of cancer diagnosis and treatment, while also accelerating cancer progression through neuroendocrine and inflammatory pathways. Early psychological assessments, combined with interventions, such as cognitive-behavioral therapy and microbiota-based therapies, can optimize clinical outcomes, enhance treatment adherence, and improve quality of life. Tailored, culturally sensitive strategies are crucial for advancing precision medicine.
Publish Date	2024-11-29 08:40
Citation	<p>Priego-Parra BA, Remes-Troche JM. Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis. <i>World J Gastroenterol</i> 2024; 30(48): 5104-5110</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i48/5104.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i48.5104

Full Article (PDF)	WJG-30-5104-with-cover.pdf
Manuscript File	100077_Auto_Edited_013033.docx
Answering Reviewers	100077-answering-reviewers.pdf
Audio Core Tip	100077-audio.mp3
Conflict-of-Interest Disclosure Form	100077-conflict-of-interest-statement.pdf
Copyright License Agreement	100077-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100077-non-native-speakers.pdf
Peer-review Report	100077-peer-reviews.pdf
Scientific Misconduct Check	100077-scientific-misconduct-check.png
Scientific Editor Work List	100077-scientific-editor-work-list.pdf
CrossCheck Report	100077-crosscheck-report.pdf