Publication Name	World Journal of Gastroenterology
Manuscript ID	100209
Country	Italy

Received	2024-08-09 22:58
Peer-Review Started	2024-08-09 22:58
To Make the First Decision
Return for Revision	2024-09-20 01:33
Revised	2024-09-27 00:09
Second Decision	2024-10-08 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-08 06:21
Articles in Press	2024-10-08 06:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-10-14 22:42
Typeset the Manuscript	2024-10-15 07:03
Publish the Manuscript Online	2024-10-23 04:32

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	MicroRNA-206 as promising epigenetic approach to modulate tumor-associated macrophages in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Davide Ramoni and Fabrizio Montecucco
Funding Agency and Grant Number
Corresponding Author	Fabrizio Montecucco, MD, PhD, Full Professor, First Clinic of Internal Medicine, Department of Internal Medicine, IRCCS Ospedale Policlinico San Martino, 6 Viale Benedetto XV, Genoa 16132, Italy. fabrizio.montecucco@unige.it
Key Words	Epigenetic regulation; Hepatocellular carcinoma; Non-coding RNAs; MicroRNA-206; Tumor-associated macrophages; Tumor microenvironment
Core Tip	Hepatocellular carcinoma is a highly aggressive tumor often associated with chronic liver disease and cirrhosis, with limited treatment options for patients ineligible for surgery or transplantation. As a result, there is an urgent need to explore alternative therapeutic options. This letter highlights the modulation of M2-tumor-associated macrophages polarization via Wnt/β-catenin and other pathways, as well as the role of microRNAs (miR)-206 in promoting anti-tumor immunity. miR-206 stimulates M1 Kupffer cell polarization, recruits cluster of differentiation 8 + T cells, and inhibits the expansion of liver cancer stem cells. Understanding these mechanisms could pave the way for targeted therapies that improve outcomes for hepatocellular carcinoma patients.
Publish Date	2024-10-23 04:32
Citation	<p>Ramoni D, Montecucco F. MicroRNA-206 as promising epigenetic approach to modulate tumor-associated macrophages in hepatocellular carcinoma. <i>World J Gastroenterol</i> 2024; 30(41): 4503-4508</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i41/4503.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i41.4503

Full Article (PDF)	WJG-30-4503-with-cover.pdf
Manuscript File	100209_Auto_Edited_054004.docx
Answering Reviewers	100209-answering-reviewers.pdf
Audio Core Tip	100209-audio.m4a
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Scientific Editor Work List	100209-scientific-editor-work-list.pdf
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CrossCheck Report	100209-crosscheck-report.pdf