Publication Name	World Journal of Clinical Cases
Manuscript ID	100223
Country	Croatia

Received	2024-08-10 09:23
Peer-Review Started	2024-08-10 09:23
To Make the First Decision
Return for Revision	2024-10-25 02:58
Revised	2024-11-06 13:31
Second Decision	2024-12-02 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-02 07:54
Articles in Press	2024-12-02 07:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-11 05:02
Publish the Manuscript Online	2024-12-19 01:57

ISSN	2307-8960 (online)
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Category	Hematology
Manuscript Type	Minireviews
Article Title	Beta thalassemia syndromes: New insights
Manuscript Source	Invited Manuscript
All Author List	Ana Dordevic, Ines Mrakovcic-Sutic, Sonja Pavlovic, Milena Ugrin and Jelena Roganovic
Funding Agency and Grant Number
Corresponding Author	Jelena Roganovic, MD, PhD, Department of Pediatric Hematology and Oncology, Children’s Hospital Zagreb, Klaiceva 16, Zagreb 10000, Croatia. jelena.roganovic@kdb.hr
Key Words	Beta thalassemia; Hemoglobin; Molecular defects; Ineffective erythropoiesis; Hemolysis; Transfusion; Iron chelation; Novel therapies
Core Tip	Beta thalassemia syndromes are among the most common monogenic disorders worldwide, characterized by impaired hemoglobin synthesis that leads to ineffective erythropoiesis, chronic hemolysis, iron overload, and subsequent complications. The clinical manifestations are diverse, as a result of the underlying beta-globin gene variants and the coinheritance of modifying factors. Recent advances in the understanding of the underlying molecular and cellular mechanisms have facilitated the development of novel therapeutic strategies. The purpose of this article is to briefly describe new insights in the pathophysiology of this old disease, and discuss revolutionary changes in the treatment landscape for severe forms of beta thalassemia.
Publish Date	2024-12-19 01:57
Citation	<p>Dordevic A, Mrakovcic-Sutic I, Pavlovic S, Ugrin M, Roganovic J. Beta thalassemia syndromes: New insights. <i>World J Clin Cases</i> 2025; 13(10): 100223</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i10/100223.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i10.100223

Full Article (PDF)	WJCC-13-100223-with-cover.pdf
Manuscript File	100223_Auto_Edited_020402.docx
Answering Reviewers	100223-answering-reviewers.pdf
Audio Core Tip	100223-audio.m4a
Conflict-of-Interest Disclosure Form	100223-conflict-of-interest-statement.pdf
Copyright License Agreement	100223-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100223-non-native-speakers.pdf
Peer-review Report	100223-peer-reviews.pdf
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Scientific Editor Work List	100223-scientific-editor-work-list.pdf
CrossCheck Report	100223-crosscheck-report.pdf