Publication Name	World Journal of Gastroenterology
Manuscript ID	100785
Country	China

Received	2024-08-27 08:35
Peer-Review Started	2024-08-29 00:18
To Make the First Decision
Return for Revision	2024-11-30 06:56
Revised	2024-12-13 14:08
Second Decision	2025-02-13 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-13 03:25
Articles in Press	2025-02-13 03:25
Publication Fee Transferred	2024-12-17 08:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-27 08:37
Publish the Manuscript Online	2025-03-13 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Ru Niu, Mi-dan Xiang, Wen-Wei Yang, Yu-Ting Fang, Hai-Li Qian and Yong-Kun Sun
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82072756 Beijing Xisike Clinical Oncology Research Foundation Y-HR2019-0285
Corresponding Author	Yong-Kun Sun, PhD, Chief Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. hsunyk@cicams.ac.cn
Key Words	Colorectal cancer; Chemotherapy resistance; Glycolysis; SIRT1; NAD+
Core Tip	SIRT1, a NAD+-dependent deacetylase, has demonstrated anti-tumor effects in numerous studies. However, the role of SIRT1 in regulating oxaliplatin resistance remains unclear. This study found that SIRT1 expression is downregulated in oxaliplatin-resistant colorectal cancer (CRC) cell. Enhancing SIRT1 expression reverses this resistance. Mechanistically, DNA damage-induced PARP activation inhibits SIRT1 expression. The inhibition of SIRT1 promotes drug resistance in CRC cells by enhancing glycolysis. These findings highlight the critical role of SIRT1 in oxaliplatin resistance and support the potential of combining SIRT1 agonists with oxaliplatin as a therapeutic strategy to overcome CRC resistance.
Publish Date	2025-03-13 10:10
Citation	<p>Niu YR, Xiang MD, Yang WW, Fang YT, Qian HL, Sun YK. NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer. <i>World J Gastroenterol</i> 2025; 31(11): 100785</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i11/100785.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i11.100785

Full Article (PDF)	WJG-31-100785-with-cover.pdf
The ARRIVE Guidelines	100785-The-ARRIVE-Guidelines.pdf
Manuscript File	100785_Auto_Edited_054456.docx
Answering Reviewers	100785-answering-reviewers.pdf
Audio Core Tip	100785-audio.mp3
Biostatistics Review Certificate	100785-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	100785-conflict-of-interest-statement.pdf
Copyright License Agreement	100785-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	100785-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	100785-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	100785-non-native-speakers.pdf
Peer-review Report	100785-peer-reviews.pdf
Scientific Misconduct Check	100785-scientific-misconduct-check.png
Scientific Editor Work List	100785-scientific-editor-work-list.pdf
CrossCheck Report	100785-crosscheck-report.pdf