Publication Name	World Journal of Gastroenterology
Manuscript ID	100946
Country	Tunisia

Received	2024-08-30 22:47
Peer-Review Started	2024-08-30 22:47
To Make the First Decision
Return for Revision	2024-09-20 00:58
Revised	2024-10-03 05:57
Second Decision	2024-10-29 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 05:27
Articles in Press	2024-10-29 05:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-04 06:49
Typeset the Manuscript	2024-11-13 03:06
Publish the Manuscript Online	2024-11-21 07:04

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Anis Hasnaoui, Racem Trigui and Mario Giuffrida
Funding Agency and Grant Number
Corresponding Author	Anis Hasnaoui, MD, Assistant Professor, Faculty of Medicine of Tunis, Tunis El Manar University, 15, Djebel Lakhdhar St, Bab Saadoun Tunis 1007, Tunisia. hasnaouianis001@gmail.com
Key Words	Cronh’s disease; Intestinal microbiota; Dysbiosis; Intestinal barrier; Mesenteric adipose tissue; Creeping fat; Fecal microbiota transplantation
Core Tip	Understanding the interplay between gut microbiota, mesenteric adipose tissue, and creeping fat is crucial in Crohn’s disease (CD) management. Dysbiosis, which is characterized by a decrease in beneficial bacteria and an increase in pathogenic ones, exacerbates inflammation and disease progression. Targeting these microbial imbalances and the inflammatory roles of mesenteric adipose tissue and creeping fat may lead to novel therapeutic approaches, including fecal microbiota transplantation, which shows promise in restoring microbial balance and achieving sustained remission in CD patients. Ongoing research should be focused on identifying specific microbial communities and their roles in different phenotypes to optimize personalized treatment strategies and improve clinical outcomes.
Publish Date	2024-11-21 07:04
Citation	<p>Hasnaoui A, Trigui R, Giuffrida M. Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease. <i>World J Gastroenterol</i> 2024; 30(46): 4969-4976</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i46/4969.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i46.4969

Full Article (PDF)	WJG-30-4969-with-cover.pdf
Manuscript File	100946_Auto_Edited_012442.docx
Answering Reviewers	100946-answering-reviewers.pdf
Audio Core Tip	100946-audio.mp3
Conflict-of-Interest Disclosure Form	100946-conflict-of-interest-statement.pdf
Copyright License Agreement	100946-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	100946-non-native-speakers.pdf
Peer-review Report	100946-peer-reviews.pdf
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Scientific Editor Work List	100946-scientific-editor-work-list.pdf
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CrossCheck Report	100946-crosscheck-report.pdf