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12/30/2024 10:50:49 AM | Browse: 112 | Download: 86
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Received |
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2024-09-09 21:48 |
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Peer-Review Started |
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2024-09-10 06:48 |
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To Make the First Decision |
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Return for Revision |
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2024-11-12 06:59 |
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Revised |
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2024-11-13 13:02 |
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Second Decision |
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2024-12-11 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-12-11 09:57 |
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Articles in Press |
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2024-12-11 09:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-12-19 09:13 |
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Publish the Manuscript Online |
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2024-12-30 09:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Renal effects and safety of tirzepatide in subjects with and without diabetes: A systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abul Bashar Mohammad Kamrul-Hasan, Shinjan Patra, Deep Dutta, Lakshmi Nagendra, AFM Muntahi-Reza, Sanja Borozan and Joseph M Pappachan |
| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph M Pappachan, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust & Manchester Metropolitan University, Sharoe Green Lane, Lower Ormond St, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in |
| Key Words |
Tirzepatide; Type 2 diabetes; Obesity; Urine albumin creatinine ratio; Estimated glomerular filtration rate; Renal safety; Acute kidney injury; Chronic kidney disease |
| Core Tip |
It is important to appraise the renal impacts and safety profile of Tirzepatide for optimal use of this molecule by clinicians for managing patients with type 2 diabetes (T2D), the most common cause of chronic kidney disease across the globe. Based on 15 randomized controlled trials (RCTs) with mostly low risk of bias involving 14471 participants, this systematic review identified that Tirzepatide significantly reduces urine albumin-to-creatinine ratio compared to placebo and insulin, with a neutral impact on estimated glomerular filtration rate (eGFR) in individuals with T2D and obesity without T2D. Moreover, tirzepatide does not appear to increase the risks of renal adverse events. Larger and longer-term RCTs are warranted to prove the renal benefits of tirzepatide and its potential to prevent eGFR decline in patients. |
| Publish Date |
2024-12-30 09:47 |
| Citation |
<p>Kamrul-Hasan ABM, Patra S, Dutta D, Nagendra L, Muntahi-Reza A, Borozan S, Pappachan JM. Renal effects and safety of tirzepatide in subjects with and without diabetes: A systematic review and meta-analysis. <i>World J Diabetes</i> 2025; 16(2): 101282</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i2/101282.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i2.101282 |
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