Publication Name	World Journal of Hepatology
Manuscript ID	101493
Country	China

Received	2024-09-19 00:30
Peer-Review Started	2024-09-19 02:21
To Make the First Decision
Return for Revision	2024-10-09 03:36
Revised	2024-10-15 14:17
Second Decision	2024-10-29 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 11:29
Articles in Press	2024-10-29 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-31 12:33
Publish the Manuscript Online	2024-11-29 14:50

ISSN	1948-5182 (online)
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Category	Agriculture, Dairy & Animal Science
Manuscript Type	Editorial
Article Title	Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Jia-Yi Du, Chu-Ting Zhang, Ting Li and Ya-Ping Li
Funding Agency and Grant Number
Corresponding Author	Ya-Ping Li, MD, PhD, Department of Infectious Diseases, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West 5th Road, Xincheng District, Xi’an 710004, Shaanxi Province, China. liyaping8605@xjtu.edu.cn
Key Words	Hepatocellular carcinoma; Hypoxia-inducible factor-1α; Angiopoietin-2; Angiogenesis; Tumor microenvironment
Core Tip	In hepatocellular carcinoma (HCC) progression, hypoxia-inducible factor-1α (HIF-1α) promotes tumor angiogenesis, invasion, and metastasis by upregulating angiopoietin-2 (Ang-2), particularly within the hypoxic microenvironment. The synergistic interaction between HIF-1α and Ang-2 not only facilitates tumor cell epithelial-mesenchymal transition but may also contribute to multidrug resistance. Therefore, targeting the HIF-1α/Ang-2 axis holds promise as a therapeutic strategy to inhibit HCC metastasis and improve patient prognosis. Moreover, Ang-2 may serve as a potential biomarker for early HCC diagnosis and progression monitoring.
Publish Date	2024-11-29 14:50
Citation	<p>Du JY, Zhang CT, Li T, Li YP. Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies. <i>World J Hepatol</i> 2024; 16(12): 1371-1376</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i12/1371.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i12.1371

Full Article (PDF)	WJH-16-1371-with-cover.pdf
Manuscript File	101493_Auto_Edited_020512.docx
Answering Reviewers	101493-answering-reviewers.pdf
Audio Core Tip	101493-audio.mp3
Conflict-of-Interest Disclosure Form	101493-conflict-of-interest-statement.pdf
Copyright License Agreement	101493-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	101493-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	101493-non-native-speakers.pdf
Peer-review Report	101493-peer-reviews.pdf
Scientific Misconduct Check	101493-scientific-misconduct-check.png
Scientific Editor Work List	101493-scientific-editor-work-list.pdf
CrossCheck Report	101493-crosscheck-report.pdf