| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Minireviews |
| Article Title |
Role of nitric oxide in cerebral ischemia/reperfusion injury: A biomolecular overview
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Roberto Anaya-Prado, Abraham I Canseco-Villegas, Roberto Anaya-Fernández, Michelle Marie Anaya-Fernandez, Miguel A Guerrero-Palomera, Citlalli Guerrero-Palomera, Ivan F Garcia-Ramirez, Daniel Gonzalez-Martinez, Consuelo Cecilia Azcona-Ramírez, Claudia Garcia-Perez, Airim L Lizarraga-Valencia, Aranza Hernandez-Zepeda, Jacqueline F Palomares-Covarrubias, Jorge HA Blackaller-Medina, Jacqueline Soto-Hintze, Mayra C Velarde-Castillo and Dayri A Cruz-Melendrez |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Roberto Anaya-Prado, MD, PhD, Professor, Department of Research & Department of Surgery, School of Medicine and Health Sciences, Tecnologico de Monterrey, Corporate Hospitals Puerta de Hierr, Blvd Puerta de Hierro, No. 5150 Int 201B. Fraccionamiento Puerta de Hierro, Zapopan 45116, Jalisco, Mexico. robana1112@gmail.com |
| Key Words |
Nitric oxide; Cerebral ischemia/reperfusion injury; Nitric oxide synthase; Reactive nitrogen species; Nitrosylation |
| Core Tip |
Nitric oxide (NO) plays a key role in cerebral ischemia/reperfusion injury (CIRI). Ischemic episodes lead to mitochondrial and phospholipid damage. While reperfusion is associated with neuronal damage by promoting lipid peroxidation, nitrosylation and excitotoxicity. Neural NO synthase (nNOS) interplay is prone to endothelial inflammation, oxidative stress and apoptosis. Therefore, nNOS appears to be detrimental. The interaction between NO and other free radicals develops peroxynitrite. And, limiting the negative effects of NO-derived compounds has been implemented as an important strategy to improve neurological outcomes after CIRI. |
| Publish Date |
2024-12-19 01:57 |
| Citation |
<p>Anaya-Prado R, Canseco-Villegas AI, Anaya-Fernández R, Anaya-Fernandez MM, Guerrero-Palomera MA, Guerrero-Palomera C, Garcia-Ramirez IF, Gonzalez-Martinez D, Azcona-Ramírez CC, Garcia-Perez C, Lizarraga-Valencia AL, Hernandez-Zepeda A, Palomares-Covarrubias JF, Blackaller-Medina JH, Soto-Hintze J, Velarde-Castillo MC, Cruz-Melendrez DA. Role of nitric oxide in cerebral ischemia/reperfusion injury: A biomolecular overview. <i>World J Clin Cases</i> 2025; 13(10): 101647</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i10/101647.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i10.101647 |
