| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Hui Zhang, Su-Tong Liu, Qing Zhao, Xiao-Yan Liu, Tong Liu, Qiang Zhang, Minghao Liu and Wen-Xia Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Province's "Double First-Class" Creation of Scientific Research in Traditional Chinese Medicine |
No. HSRP-DFCTCM-2023-7-23 |
| Henan Province's "Double First-Class" Creation of Scientific Research in Traditional Chinese Medicine |
No. STG-ZYX02-202117 |
| National Traditional Chinese Medicine Clinical Research Base Scientific Research Special Project |
No. 2022JDZX098 |
| National Traditional Chinese Medicine Clinical Research Base Scientific Research Special Project |
No. 2022JDZX114 |
| National Natural Science Foundation of China |
No. 82205086 |
| The 9th China Association for Science and Technology Young Talent Support Project |
No. 2023QNRC001 |
|
| Corresponding Author |
Wen-Xia Zhao, Chief Physician, MD, Professor, Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China. zhao-wenxia@163.com |
| Key Words |
Triggering receptor expressed on myeloid cells 2; Non-alcoholic fatty liver disease; Macrophage; Lipid metabolism; Inflammation |
| Core Tip |
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin superfamily receptor located on the cell membrane. In the liver, it is mainly expressed on macrophages. TREM2 plays an important regulatory role in lipid metabolism, inflammation, fibrosis, and hepatocellular carcinoma, and is considered a potential therapeutic target for non-alcoholic fatty liver disease (NAFLD) (for example, macrophages with high expression of TREM2 can effectively clear apoptotic liver cells in a timely manner), thereby inhibiting chronic liver inflammation and non-alcoholic steatohepatitis lesions caused by obesity. This article highlights the most recent research developments on TREM2 in NAFLD, in an attempt to identify new pathways for NAFLD treatment. |
| Publish Date |
2025-02-20 08:39 |
| Citation |
<p>Zhang LH, Liu ST, Zhao Q, Liu XY, Liu T, Zhang Q, Liu M, Zhao WX. Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease. <i>World J Hepatol</i> 2025; 17(2): 102328</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i2/102328.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i2.102328 |
