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2/28/2025 11:47:27 AM | Browse: 107 | Download: 91
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2025-02-05 02:41 |
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Accepted by Journal Editor-in-Chief |
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2025-02-05 04:02 |
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2025-02-28 10:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Editorial |
| Article Title |
Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Meng Gao, Meng-Ting Dai and Guo-Hua Gong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Basic Research Project of Wenzhou Municipal Science and Technology Bureau |
No. Y20240008 |
| The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission |
No. 2024KY138 |
| The Key Laboratory of School of Laboratory Medicine and Life Sciences, Wenzhou Medical University of China |
No. JS2023003 |
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| Corresponding Author |
Guo-Hua Gong, PhD, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Chashan Higher Education Park, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn |
| Key Words |
Glucose metabolism; Sodium-D-glucose cotransporter 1; Glucose reabsorption; Mitochondrial dysfunction; Reactive oxygen species; Inflammation |
| Core Tip |
In diabetes, insulin resistance and insufficient insulin release lead to a decrease in glucose uptake by muscles and fat tissues, resulting in elevated blood glucose levels, which are dangerous to human organs. The tolerance of high glucose switches the metabolism of glucose, which causes mitochondrial dysfunction. Oxidative stress induced by excess reactive oxygen species generated by dysfunctional mitochondria causes cell damage and thus stimulates proinflammatory factor production and tissue injury. Therefore, antidiabetic therapies are aimed at decreasing blood glucose and oxidative stress. |
| Publish Date |
2025-02-28 10:47 |
| Citation |
<p>Gao M, Dai MT, Gong GH. Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes. <i>World J Diabetes</i> 2025; 16(4): 102554</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i4/102554.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i4.102554 |
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