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5/15/2025 12:25:58 PM | Browse: 27 | Download: 92
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Received |
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2024-11-05 02:00 |
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Peer-Review Started |
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2024-11-05 02:00 |
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To Make the First Decision |
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Return for Revision |
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2025-02-10 08:13 |
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Revised |
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2025-02-14 12:45 |
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Second Decision |
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2025-03-07 03:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-03-07 07:53 |
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Articles in Press |
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2025-03-07 07:53 |
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Publication Fee Transferred |
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2025-02-21 14:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-27 08:52 |
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Publish the Manuscript Online |
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2025-05-15 10:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Homologous recombination deficiency and immunotherapy response in microsatellite-stable colorectal cancer: Evidence from a cohort study in China
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Feng, Li-Ying Zhao, Zhou Xu, Qing-Feng Xie, Hai-Jun Deng, Jiang Yu and Hao Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangdong Province of China |
2021A1515011146 and 2023A1515010785 |
| Key Areas Research and Development Programs of Guangdong Province |
2023B1111050009 |
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| Corresponding Author |
Hao Liu, MD, PhD, Professor, Department of General Surgery, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Ave. North, Guangzhou 510515, Guangdong Province, China. liuhaofbi@163.com |
| Key Words |
Colorectal cancer; Homologous recombination deficiency; Microsatellite-stable; Prognosis; Immunotherapy |
| Core Tip |
This study evaluates the effectiveness of immunotherapy in microsatellite-stable (MSS) colorectal cancer (CRC) patients with homologous recombination deficiency (HRD). By analyzing 268 CRC patients through next-generation sequencing, the research identifies a significant correlation between HRD status and improved survival outcomes. Notably, MSS patients with HRD exhibited better prognoses when treated with immunotherapy compared to those with homologous recombination proficiency. These findings suggest that HRD status may serve as a critical predictive marker for immunotherapy response in MSS CRC patients. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Feng H, Zhao LY, Xu Z, Xie QF, Deng HJ, Yu J, Liu H. Homologous recombination deficiency and immunotherapy response in microsatellite-stable colorectal cancer: Evidence from a cohort study in China. <i>World J Gastrointest Oncol</i> 2025; 17(5): 102767</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/102767.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.102767 |
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