Publication Name	World Journal of Gastroenterology
Manuscript ID	102848
Country	China

Received	2024-11-11 10:09
Peer-Review Started	2024-11-11 10:09
To Make the First Decision
Return for Revision	2025-01-03 22:16
Revised	2025-01-17 14:12
Second Decision	2025-02-11 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-11 07:12
Articles in Press	2025-02-11 07:12
Publication Fee Transferred	2025-01-21 08:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-05 02:55
Publish the Manuscript Online	2025-03-13 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Wu, Bin-Bin Xie, Bing-Liang Zhang, Qing-Xin Zhuang, Shi-Wei Liu and Hong-Ming Pan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China for Young Scientists 82100542 and 81802842
Corresponding Author	Hong-Ming Pan, Division of Cancer Medicine, Sir Run Run Shaw Medical Center, Zhejiang University School of Medicine, No. 3 East Qinchun Road, Hangzhou 310016, Zhejiang Province, China. panhongming@zju.edu.cn
Key Words	Apatinib; Hepatocellular carcinoma; Vascular endothelial cells; Glycolysis; Phosphatidylinositol 3-kinase; Protein kinase B; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Core Tip	Hepatocellular carcinoma (HCC) is characterized by its rich vascularization and highly active metabolic processes. As a vascular endothelial growth factor receptor-2-targeting agent, apatinib serves as a primary therapeutic option for HCC patients. Nevertheless, the impact of apatinib on the metabolic activities of vascular endothelial cells remains poorly understood. The study revealed that apatinib modulates glycolysis in HCC-associated vascular endothelial cells through the phosphatidylinositol 3-kinase/AKT/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 signaling cascade. These findings provide insights into the molecular mechanism of apatinib’s action on endothelial cells and uncover a potential therapeutic target for HCC patients with high 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 expression.
Publish Date	2025-03-13 10:10
Citation	<p>Wu Y, Xie BB, Zhang BL, Zhuang QX, Liu SW, Pan HM. Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma. <i>World J Gastroenterol</i> 2025; 31(11): 102848</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i11/102848.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i11.102848

Full Article (PDF)	WJG-31-102848-with-cover.pdf
The ARRIVE Guidelines	102848-The-ARRIVE-Guidelines.pdf
Manuscript File	102848_Auto_Edited_074900.docx
Answering Reviewers	102848-answering-reviewers.pdf
Audio Core Tip	102848-audio.mp3
Biostatistics Review Certificate	102848-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102848-conflict-of-interest-statement.pdf
Copyright License Agreement	102848-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102848-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102848-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	102848-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102848-non-native-speakers.pdf
Supplementary Material	102848-supplementary-material.pdf
Peer-review Report	102848-peer-reviews.pdf
Scientific Misconduct Check	102848-scientific-misconduct-check.png
Scientific Editor Work List	102848-scientific-editor-work-list.pdf
CrossCheck Report	102848-crosscheck-report.pdf