Publication Name	World Journal of Gastroenterology
Manuscript ID	103094
Country	China

Received	2024-11-10 15:04
Peer-Review Started	2024-11-10 15:04
To Make the First Decision
Return for Revision	2024-12-26 23:13
Revised	2025-01-09 21:12
Second Decision	2025-02-21 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-21 06:24
Articles in Press	2025-02-21 06:24
Publication Fee Transferred	2025-01-15 17:10
Edit the Manuscript by Language Editor	2025-02-26 13:36
Typeset the Manuscript	2025-03-18 00:28
Publish the Manuscript Online	2025-03-26 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	scRNA-seq of the intestine reveals mast cells' key role in early gut dysfunction associated with acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Zu-Xing Wei, Shi-He Jiang, Xiao-Yan Qi, Yi-Miao Cheng, Qiong Liu, Xu-Yang Hou and Jun He
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82300739 Hunan Provincial Natural Science Foundation 2023JJ40821 Changsha Natural Science Foundation kq2208308
Corresponding Author	Jun He, MD, Department of General Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha 410011, Hunan Province, China. junjunhe@csu.edu.cn
Key Words	Single-cell RNA sequencing; Acute pancreatitis; Mast cell; CCL5; Intestinal barrier function
Core Tip	Our study provides a comprehensive picture of the transcriptome of small intestine cells during the early stage of AP, revealing a total of 33,232 cells across all samples and 17 main clusters. Through our investigation, we established that MCs were promptly activated in the intestine, and we identified CCL5 derived from MCs as an indispensable factor contributing to the infiltration of inflammatory cells and the progression of gut barrier dysfunction.
Publish Date	2025-03-26 08:40
Citation	<p>Wei ZX, Jiang SH, Qi XY, Cheng YM, Liu Q, Hou XY, He J. scRNA-seq of the intestine reveals mast cells' key role in early gut dysfunction associated with acute pancreatitis. <i>World J Gastroenterol</i> 2025; 31(12): 103094</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i12/103094.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i12.103094

Full Article (PDF)	WJG-31-103094-with-cover.pdf
The ARRIVE Guidelines	103094-The-ARRIVE-Guidelines.pdf
Manuscript File	103094_Auto_Edited_064332.docx
Answering Reviewers	103094-answering-reviewers.pdf
Audio Core Tip	103094-audio.m4a
Biostatistics Review Certificate	103094-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103094-conflict-of-interest-statement.pdf
Copyright License Agreement	103094-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103094-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103094-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	103094-non-native-speakers.pdf
Supplementary Material	103094-supplementary-material.zip
Peer-review Report	103094-peer-reviews.pdf
Scientific Misconduct Check	103094-scientific-misconduct-check.png
Scientific Editor Work List	103094-scientific-editor-work-list.pdf
CrossCheck Report	103094-crosscheck-report.png
CrossCheck Report	103094-crosscheck-report.pdf