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6/6/2025 6:59:32 AM | Browse: 26 | Download: 52
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Received |
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2024-11-19 08:52 |
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Peer-Review Started |
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2024-11-19 08:53 |
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To Make the First Decision |
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Return for Revision |
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2025-03-08 05:30 |
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Revised |
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2025-03-26 08:49 |
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Second Decision |
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2025-04-22 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-22 06:12 |
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Articles in Press |
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2025-04-22 06:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-30 09:01 |
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Publish the Manuscript Online |
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2025-06-06 03:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Mechanisms underlying hepatocellular carcinoma progression through N6-methyladenosine modifications of long non-coding RNA
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ning Wang, Fei-Tian Min, Wei-Bo Wen and Huan-Tian Cui |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82405223 |
| Yunling Scholars Program |
XDYC-YLXZ-2022-0027 |
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| Corresponding Author |
Huan-Tian Cui, PhD, The First School of Clinical Medicine, Yunnan university of Chinese Medicine, No. 1076 Yuhua Road, Chenggong District, Kunming 650000, Yunnan Province, China. 1762316411@qq.com |
| Key Words |
Hepatocellular carcinoma; Stemness; Sorafenib resistance; Long non-coding RNA KIF9-AS1; Short stature homeobox 2; N6-methyladenosine |
| Core Tip |
Yu et al present evidence showing that m6A-modified long non-coding RNA KIF9-AS1 drives the progression of hepatocellular carcinoma (HCC) and reveal novel molecular mechanisms underlying this process. The m6A modification, mediated by modification involves methyltransferase-like 3 and insulin-like growth factor insulin-like growth factor 2 mRNA-binding protein 1, stabilizes and upregulates KIF9-AS1 expression. In turn, KIF9-AS1 enhances the stability and expression of SHOX2 by promoting its deubiquitination via ubiquitin-specific peptidase 1, which strengthens stemness and contributes to sorafenib resistance in HCC cells. Future studies should further validate KIF9-AS1 as a potential diagnostic biomarker for HCC and explore its therapeutic applications in HCC treatment. |
| Publish Date |
2025-06-06 03:09 |
| Citation |
<p>Wang N, Min FT, Wen WB, Cui HT. Mechanisms underlying hepatocellular carcinoma progression through N6-methyladenosine modifications of long non-coding RNA. <i>World J Gastroenterol</i> 2025; 31(21): 103184</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i21/103184.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i21.103184 |
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