Publication Name	World Journal of Critical Care Medicine
Manuscript ID	103458
Country	Egypt

Received	2024-11-20 04:49
Peer-Review Started	2024-11-20 04:49
To Make the First Decision
Return for Revision	2025-02-28 06:05
Revised	2025-03-04 22:07
Second Decision	2025-03-11 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-11 09:19
Articles in Press	2025-03-11 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-17 13:03
Typeset the Manuscript	2025-05-30 05:53
Publish the Manuscript Online	2025-07-18 15:29

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Minireviews
Article Title	Klotho: A multifaceted protector in sepsis-induced organ damage and a potential therapeutic target
Manuscript Source	Invited Manuscript
All Author List	Alaa Al-Kadi, Aliaa Anter, Remon R Rofaeil, Mohamed M Sayed-Ahmed and Al-Shaimaa F Ahmed
Funding Agency and Grant Number
Corresponding Author	Al-Shaimaa F Ahmed, Associate Professor, PhD, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Cairo-Aswan Agriculture Road, Minia 61511, Egypt. shaimaa.faissal@minia.edu.eg
Key Words	Sepsis; Aging; Klotho; Cell signaling; Inflammation; Oxidation
Core Tip	Klotho, originally identified as an anti-aging protein, plays a critical role in mitigating sepsis-induced organ dysfunction by reducing oxidative stress, inflammation, and apoptosis. This review highlights klotho's potential as a therapeutic target, exploring its ability to modulate key signaling pathways like nuclear factor-kappa β, mitogen activated protein kinase, and nuclear factor erythroid-related factor 2. Reduced klotho levels correlate with increased severity of sepsis, while its supplementation shows promise in improving survival rates and alleviating organ damage. Understanding the mechanisms of klotho's cytoprotective effects may pave the way for novel treatments in managing sepsis-related organ failure.
Publish Date	2025-07-18 15:29
Citation	<p>Al-Kadi A, Anter A, Rofaeil RR, Sayed-Ahmed MM, Ahmed ASF. Klotho: A multifaceted protector in sepsis-induced organ damage and a potential therapeutic target. <i>World J Crit Care Med</i> 2025; 14(3): 103458</p>
URL	https://www.wjgnet.com/2220-3141/full/v14/i3/103458.htm
DOI	https://dx.doi.org/10.5492/wjccm.v14.i3.103458

Full Article (PDF)	WJCCM-14-103458-with-cover.pdf
Manuscript File	103458_Auto_Edited_081926.docx
Answering Reviewers	103458-answering-reviewers.pdf
Audio Core Tip	103458-audio.mp4
Conflict-of-Interest Disclosure Form	103458-conflict-of-interest-statement.pdf
Copyright License Agreement	103458-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	103458-non-native-speakers.pdf
Peer-review Report	103458-peer-reviews.pdf
Scientific Misconduct Check	103458-scientific-misconduct-check.png
Scientific Editor Work List	103458-scientific-editor-work-list.pdf
CrossCheck Report	103458-crosscheck-report.pdf