| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Pig bile powder maintains blood glucose homeostasis by promoting glucagon-like peptide-1 secretion via inhibiting farnesoid X receptor
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Min Sun, Jun-Liang Kuang, Hui-Heng Zhang, Xi-Xi Xia, Jie-Yi Wang, Dan Zheng, Ke-Jun Zhou, Ya-Jun Tang, Ai-Hua Zhao, Wei Jia, Guo-Xiang Xie and Xiao-Jiao Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82122012 |
| National Natural Science Foundation of China |
No. 82270917 |
| National Natural Science Foundation of China |
No. 82170833 |
| National Natural Science Foundation of China |
No. 82170601 |
| Shanghai Sixth People’s Hospital Project |
No. ynjq202401 |
| Shanghai Sixth People’s Hospital Project |
No. ynms202117 |
| Shanghai Research Center for Endocrine and Metabolic Diseases |
No. 2022ZZ01002 |
|
| Corresponding Author |
Xiao-Jiao Zheng, Center for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. joyzheng99@sjtu.edu.cn |
| Key Words |
Pig bile powder; Type 2 diabetes mellitus; Glucagon-like peptide 1; Farnesoid X receptor; Traditional Chinese medicine |
| Core Tip |
Traditional Chinese medicine has several substances that regulate blood glucose in the treatment of type 2 diabetes mellitus. One of these substances is pig bile powder (BP). However, its mechanism of action remains unclear. This study demonstrated that BP treatment improved glucose tolerance and insulin sensitivity in a diabetic mouse model. Bile acids in the BP act as farnesoid X receptor antagonists and enhance glucagon-like peptide-1 production. Glucagon-like peptide-1 is a key hormone for glucose regulation. Our findings furthered the understanding of the therapeutic potential of BP for type 2 diabetes mellitus treatment. |
| Publish Date |
2025-06-13 11:47 |
| Citation |
<p>Sun YM, Kuang JL, Zhang HH, Xia XX, Wang JY, Zheng D, Zhou KJ, Tang YJ, Zhao AH, Jia W, Xie GX, Zheng XJ. Pig bile powder maintains blood glucose homeostasis by promoting glucagon-like peptide-1 secretion via inhibiting farnesoid X receptor. <i>World J Diabetes</i> 2025; 16(6): 103616</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i6/103616.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i6.103616 |
