Publication Name	World Journal of Cardiology
Manuscript ID	103733
Country	Saudi Arabia

Received	2024-11-29 09:24
Peer-Review Started	2024-12-02 00:23
To Make the First Decision
Return for Revision	2024-12-24 10:19
Revised	2025-01-05 18:53
Second Decision	2025-01-24 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-24 06:58
Articles in Press	2025-01-24 06:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-01-25 19:39
Typeset the Manuscript	2025-02-17 10:56
Publish the Manuscript Online	2025-02-25 06:14

ISSN	1949-8462 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Moaz Safwan, Mariam Safwan Bourgleh, Aseel Alsudays and Khawaja Husnain Haider
Funding Agency and Grant Number
Corresponding Author	Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, Saudi Arabia. khhaider@gmail.com
Key Words	Amlodipine; Cardiomyopathy; Iron overload; Randomized controlled trials; Thalassemia
Core Tip	Thalassemias are the most common inherited blood disorder caused by genetic mutations that significantly reduce or abolish normal hemoglobin production altogether. Iron chelation therapy, which aims to maintain safe iron levels, eliminate deposited iron, and promptly reverse the failing heart condition, is the current treatment for iron overload in thalassemia. Our systematic review and meta-analysis attempt to establish evidence from the reported randomized controlled trials that amlodipine can effectively alleviate cardiotoxicity related to iron overload in thalassemia major patients, especially when combined with iron chelators.
Publish Date	2025-02-25 06:14
Citation	<p>Safwan M, Bourgleh MS, Alsudays A, Haider KH. Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis. <i>World J Cardiol</i> 2025; 17(2): 103733</p>
URL	https://www.wjgnet.com/1949-8462/full/v17/i2/103733.htm
DOI	https://dx.doi.org/10.4330/wjc.v17.i2.103733

Full Article (PDF)	WJC-17-103733-with-cover.pdf
PRISMA 2009 Checklist	103733-PRISMA-2009-Checklist.pdf
Manuscript File	103733_Auto_Edited_073844.docx
Answering Reviewers	103733-answering-reviewers.pdf
Audio Core Tip	103733-audio.mp3
Biostatistics Review Certificate	103733-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103733-conflict-of-interest-statement.pdf
Copyright License Agreement	103733-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	103733-non-native-speakers.pdf
Supplementary Material	103733-supplementary-material.pdf
Peer-review Report	103733-peer-reviews.pdf
Scientific Misconduct Check	103733-scientific-misconduct-check.png
Scientific Editor Work List	103733-scientific-editor-work-list.pdf
CrossCheck Report	103733-crosscheck-report.pdf