Publication Name	World Journal of Gastroenterology
Manuscript ID	103848
Country	China

Received	2024-12-04 03:52
Peer-Review Started	2024-12-04 03:52
To Make the First Decision
Return for Revision	2025-03-19 23:20
Revised	2025-03-30 13:52
Second Decision	2025-05-30 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-30 05:29
Articles in Press	2025-05-30 05:29
Publication Fee Transferred	2025-04-03 11:38
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-16 02:37
Publish the Manuscript Online	2025-06-20 09:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Bing Wang, Jia-Yi Ge, Jia-Ni Wu, Jia-Huan Xu, Xiao-Hua Cao, Na Chang, Xiang Zhou, Peng-Bo Jing, Xing-Jun Liu and Yong Wu
Funding Agency and Grant Number
Corresponding Author	Yong Wu, Chief Physician, MD, Department of Anesthesiology, The First People’s Hospital of Lianyungang, No. 6 Zhenhua East Street, Lianyungang 222000, Jiangsu Province, China. 18961325621@163.com
Key Words	Chronic pancreatitis; Abdominal pain; Endothelin; Endothelin A receptor; Calcitonin gene-related peptide; Macrophage infiltration; Microglia activation
Core Tip	Currently the mechanism underlying abdominal pain associated with chronic pancreatitis (CP) is not well understood. Utilizing dibutyltin dichloride-induced CP mouse model, it was found that the nociceptor-expressing endothelin A receptor (ETAR) is essential for the development of mechanical hypersensitivity following dibutyltin dichloride treatment. ETAR may contribute to this through regulating calcitonin gene-related peptide expression and activating immune cells. Therefore, targeting ETAR-dependent endothelin signaling in nociceptive sensory neurons may be a potential therapeutic approach for treating CP patients.
Publish Date	2025-06-20 09:55
Citation	<p>Wang B, Ge JY, Wu JN, Xu JH, Cao XH, Chang N, Zhou X, Jing PB, Liu XJ, Wu Y. Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model. <i>World J Gastroenterol</i> 2025; 31(23): 103848</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i23/103848.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i23.103848

Full Article (PDF)	WJG-31-103848-with-cover.pdf
The ARRIVE Guidelines	103848-The-ARRIVE-Guidelines.pdf
Manuscript File	103848_Auto_Edited_102330.docx
Answering Reviewers	103848-answering-reviewers.pdf
Audio Core Tip	103848-audio.mp3
Biostatistics Review Certificate	103848-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103848-conflict-of-interest-statement.pdf
Copyright License Agreement	103848-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103848-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103848-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	103848-non-native-speakers.pdf
Peer-review Report	103848-peer-reviews.pdf
Scientific Misconduct Check	103848-scientific-misconduct-check.png
Scientific Editor Work List	103848-scientific-editor-work-list.pdf
CrossCheck Report	103848-crosscheck-report.pdf