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2/25/2025 8:14:29 AM | Browse: 225 | Download: 356
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Received |
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2024-12-06 08:02 |
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2024-12-06 08:03 |
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2025-01-18 10:16 |
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2025-01-18 10:16 |
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2025-02-10 02:37 |
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2025-02-10 07:42 |
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Typeset the Manuscript |
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2025-02-14 02:44 |
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2025-02-25 06:14 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nan Tang, Kang-Ming Li, Hao-Ran Li, Qing-Dui Zhang, Ji Hao and Chun-Mei Qi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Chun-Mei Qi, PhD, Professor, Department of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, No. 32 Coal Construction Road, Quanshan District, Xuzhou 221000, Jiangsu Province, China. wwtgy12581@163.com |
| Key Words |
Adverse outcomes; Stem cell therapy; Microvascular resistance; Coronary flow reserve; Management; Diagnosis; Percutaneous coronary intervention; Coronary microvascular dysfunction |
| Core Tip |
Coronary microvascular dysfunction (CMD) is a significant cause of persistent myocardial ischemia in patients following percutaneous coronary intervention. This review highlights the complex pathophysiology of CMD, which involves endothelial dysfunction, microvascular remodeling, reperfusion injury, and metabolic abnormalities. The interplay between CMD and metabolic syndrome exacerbates microcirculatory dysfunction through inflammation, oxidative stress, and insulin resistance. Advances in diagnostic techniques, including invasive methods like coronary flow reserve and index of microcirculatory resistance, and non-invasive imaging such as positron emission tomography and cardiac magnetic resonance, have improved early detection. Management strategies emphasize a multi-level approach combining lifestyle interventions, pharmacological therapies, and specialized treatments like enhanced external counterpulsation and metabolic surgery. Future research should focus on optimizing diagnostic tools, developing precision therapies, and understanding the genetic and molecular basis of CMD to improve long-term patient outcomes. |
| Publish Date |
2025-02-25 06:14 |
| Citation |
Tang N, Li KM, Li HR, Zhang QD, Hao J, Qi CM. Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions. World J Cardiol 2025; 17(2): 103950 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i2/103950.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i2.103950 |
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