Publication Name	World Journal of Cardiology
Manuscript ID	103950
Country	China

Received	2024-12-06 08:02
Peer-Review Started	2024-12-06 08:03
To Make the First Decision
Return for Revision	2025-01-18 10:16
Revised	2025-01-28 04:53
Second Decision	2025-02-10 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-10 07:42
Articles in Press	2025-02-10 07:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-14 02:44
Publish the Manuscript Online	2025-02-25 06:14

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions
Manuscript Source	Invited Manuscript
All Author List	Nan Tang, Kang-Ming Li, Hao-Ran Li, Qing-Dui Zhang, Ji Hao and Chun-Mei Qi
Funding Agency and Grant Number
Corresponding Author	Chun-Mei Qi, PhD, Professor, Department of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, No. 32 Coal Construction Road, Quanshan District, Xuzhou 221000, Jiangsu Province, China. wwtgy12581@163.com
Key Words	Coronary microvascular dysfunction; Percutaneous coronary intervention; Diagnosis; Management; Coronary flow reserve; Microvascular resistance; Stem cell therapy; Adverse outcomes
Core Tip	Coronary microvascular dysfunction (CMD) is a significant cause of persistent myocardial ischemia in patients following percutaneous coronary intervention. This review highlights the complex pathophysiology of CMD, which involves endothelial dysfunction, microvascular remodeling, reperfusion injury, and metabolic abnormalities. The interplay between CMD and metabolic syndrome exacerbates microcirculatory dysfunction through inflammation, oxidative stress, and insulin resistance. Advances in diagnostic techniques, including invasive methods like coronary flow reserve and index of microcirculatory resistance, and non-invasive imaging such as positron emission tomography and cardiac magnetic resonance, have improved early detection. Management strategies emphasize a multi-level approach combining lifestyle interventions, pharmacological therapies, and specialized treatments like enhanced external counterpulsation and metabolic surgery. Future research should focus on optimizing diagnostic tools, developing precision therapies, and understanding the genetic and molecular basis of CMD to improve long-term patient outcomes.
Publish Date	2025-02-25 06:14
Citation	<p>Tang N, Li KM, Li HR, Zhang QD, Hao J, Qi CM. Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions. <i>World J Cardiol</i> 2025; 17(2): 103950</p>
URL	https://www.wjgnet.com/1949-8462/full/v17/i2/103950.htm
DOI	https://dx.doi.org/10.4330/wjc.v17.i2.103950

Full Article (PDF)	WJC-17-103950-with-cover.pdf
Manuscript File	103950_Auto_Edited_054725.docx
Answering Reviewers	103950-answering-reviewers.pdf
Audio Core Tip	103950-audio.mp3
Conflict-of-Interest Disclosure Form	103950-conflict-of-interest-statement.pdf
Copyright License Agreement	103950-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	103950-non-native-speakers.pdf
Peer-review Report	103950-peer-reviews.pdf
Scientific Misconduct Check	103950-scientific-misconduct-check.png
Scientific Editor Work List	103950-scientific-editor-work-list.pdf
CrossCheck Report	103950-crosscheck-report.pdf