Publication Name	World Journal of Gastroenterology
Manuscript ID	104033
Country	China

Received	2024-12-08 14:32
Peer-Review Started	2024-12-08 14:32
To Make the First Decision
Return for Revision	2025-01-22 04:54
Revised	2025-02-03 13:50
Second Decision	2025-02-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-18 06:02
Articles in Press	2025-02-18 06:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-02-19 13:02
Typeset the Manuscript	2025-03-05 02:35
Publish the Manuscript Online	2025-03-13 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Phospholipase D2: A biomarker for stratifying severity in acute pancreatitis?
Manuscript Source	Invited Manuscript
All Author List	Zhi-Hui Wang, Jia-Hui Lv, Yun Teng, Ntim Michael, Yi-Fan Zhao, Min Xia and Bin Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Sciences Foundation of China 82301700 Liaoning Province Natural Science Foundation Project 2024-MS-157 Youth Talent Cultivation Fund Key Project of Dalian Medical University Scientific Research Projects from Wuhan Municipal Health Commission WX23Z26 Science and Technology of Liaoning Province 2023-MS-266
Corresponding Author	Bin Wang, PhD, Professor, Liaoning Provincial Key Laboratory of Cerebral Diseases, College of Basic Medical Sciences, National-Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian Medical University, No. 9 West Section, Lvshun South Road, Dalian 116000, Liaoning Province, China. wb101900@126.com
Key Words	Phospholipase D2; Acute pancreatitis; Biomarker; Inflammatory response; Severity diagnosis
Core Tip	The identification of reliable biomarkers for early stratification of disease severity is essential in the management of acute pancreatitis (AP). Phospholipase D2 (PLD2), a pivotal regulator of neutrophil migration and inflammatory responses, has emerged as a promising candidate biomarker that may transform AP management by integrating molecular diagnostics with precision medicine. However, several challenges persist, including large-scale validation studies, functional investigations to establish causation, and standardization of measurement protocols. Consequently, it is imperative to critically examine and rigorously validate the role of PLD2 to ensure its effectiveness in improving patient outcomes.
Publish Date	2025-03-13 10:11
Citation	<p>Wang ZH, Lv JH, Teng Y, Michael N, Zhao YF, Xia M, Wang B. Phospholipase D2: A biomarker for stratifying severity in acute pancreatitis? <i>World J Gastroenterol</i> 2025; 31(11): 104033</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i11/104033.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i11.104033

Full Article (PDF)	WJG-31-104033-with-cover.pdf
Manuscript File	104033_Auto_Edited_024128.docx
Answering Reviewers	104033-answering-reviewers.pdf
Audio Core Tip	104033-audio.mp3
Conflict-of-Interest Disclosure Form	104033-conflict-of-interest-statement.pdf
Copyright License Agreement	104033-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104033-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	104033-non-native-speakers.pdf
Peer-review Report	104033-peer-reviews.pdf
Scientific Misconduct Check	104033-scientific-misconduct-check.png
Scientific Editor Work List	104033-scientific-editor-work-list.pdf
CrossCheck Report	104033-crosscheck-report.png
CrossCheck Report	104033-crosscheck-report.pdf