| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Nan Liao, Wen-Juan Ni, Ping-Hui Wu, Ya-Dong Yang, Ying Yang, Wen Long, Mei-Zhen Xie, Xiu-Zhi Zhu, Fu-Hua Xie and Xiao-Min Leng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangxi Provincial Natural Science Foundation |
No. 20242BAB25454 |
| Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular of Ministry of Education of Gannan Medical University |
No. XN202013 |
| Science and Technology Research Project of Jiangxi Provincial Department of Education |
No. GJJ201528 |
| Startup Foundation for Advanced Talents of Gannan Medical University |
No. QD202124 |
|
| Corresponding Author |
Xiao-Min Leng, Associate Professor, MD, PhD, School of Basic Medicine, Gannan Medical University, College Park of Rongjiang New District, Ganzhou 341000, Jiangxi Province, China. lengxm@mail2.sysu.edu.cn |
| Key Words |
METTL3; N6-methyladenosine; Epigenetics; Biomarker; Targeted treatment; Colorectal cancer |
| Core Tip |
METTL3 is a member of methyltransferase involved in N6-methyladenosine (m6A) generation, and its aberrant expression is usually associated with the occurrence and development of various diseases. Although METTL3 has been studied in the molecular pathological mechanisms of colorectal cancer (CRC), its function and regulatory mechanism in this disease are still unclear. Via m6A modification of both messenger RNAs and noncoding RNAs, METTL3 participates in CRC proliferation, invasion, drug resistance, and metabolism. Its molecular mechanisms are emphasized in regulating diverse signaling pathways during various CRC stages. As a potential biomarker or target in CRC, its clinical application in diagnosis, prognosis, and treatment is also highlighted. By reviewing the latest research progress of METTL3 in CRC, this article provides new insights into the theoretical investigation of clinical diagnosis and targeted treatment for this disease. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Liao JN, Ni WJ, Wu PH, Yang YD, Yang Y, Long W, Xie MZ, Zhu XZ, Xie FH, Leng XM. Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target. <i>World J Gastrointest Oncol</i> 2025; 17(5): 104076</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/104076.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.104076 |
