Publication Name	World Journal of Methodology
Manuscript ID	104472
Country	Greece

Received	2024-12-24 07:41
Peer-Review Started	2024-12-30 01:18
To Make the First Decision
Return for Revision	2025-03-05 10:12
Revised	2025-03-10 20:27
Second Decision	2025-03-19 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-21 02:13
Articles in Press	2025-03-21 02:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-28 11:13
Publish the Manuscript Online	2025-08-04 12:11

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Review
Article Title	Cytoprotective effect of prostacyclin on hepatic ischemia–reperfusion injury
Manuscript Source	Invited Manuscript
All Author List	Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Maria Papaioannou, Argyri Niti, Serafeim-Chrysovalantis Kotoulas, Georgios Tsoulfas, Eleni Mouloudi, Ioannis N Galanis and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, The 2nd Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Hepatic ischemia–reperfusion injury; Oxidative stress; Prostacyclin analogs; Prostaglandins; Liver transplantation; Liver graft dysfunction
Core Tip	Hepatic ischemia‒reperfusion injury is a critical event that affects the outcomes of liver surgery, transplantation and many other major clinical conditions. The reoxygenation of ischemic hepatocytes activates complex inflammatory processes, which lead to oxidative stress that has deleterious local and global consequences. Prostacyclin (PGI2) is a well-known member of the prostaglandin family with potent vasodilative, platelet-inhibiting and anti-inflammatory effects. Several reports have detailed the cytoprotective effects of PGI2 analogs on hepatic ischemia‒reperfusion injury. In this review, we discuss the underlying mechanisms of hepatic ischemia‒reperfusion injury and the potential hepatoprotective effects of PGI2 analogs.
Publish Date	2025-08-04 12:11
Citation	<p>Mouratidou C, Pavlidis ET, Katsanos G, Papaioannou M, Niti A, Kotoulas SC, Tsoulfas G, Mouloudi E, Galanis IN, Pavlidis TE. Cytoprotective effect of prostacyclin on hepatic ischemia–reperfusion injury. <i>World J Methodol</i> 2025; 15(4): 104472</p>
URL	https://www.wjgnet.com/2222-0682/full/v15/i4/104472.htm
DOI	https://dx.doi.org/10.5662/wjm.v15.i4.104472

Full Article (PDF)	WJM-15-104472-with-cover.pdf
Manuscript File	104472_Auto_Edited_084049.docx
Answering Reviewers	104472-answering-reviewers.pdf
Audio Core Tip	104472-audio.m4a
Conflict-of-Interest Disclosure Form	104472-conflict-of-interest-statement.pdf
Copyright License Agreement	104472-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	104472-non-native-speakers.pdf
Peer-review Report	104472-peer-reviews.pdf
Scientific Misconduct Check	104472-scientific-misconduct-check.png
Scientific Editor Work List	104472-scientific-editor-work-list.pdf
CrossCheck Report	104472-crosscheck-report.pdf